Effects of valproate on vestibular migraine symptom improvement and vestibular function
- VernacularTitle:丙戊酸钠对前庭性偏头痛症状改善及前庭功能的影响
- Author:
Huanhuan GU
1
;
Jianhua ZHUANG
1
Author Information
- Publication Type:Journal Article
- Keywords: Vestibular migraine; Valproate; Preventive treatment; Vestibular function
- From: Journal of Apoplexy and Nervous Diseases 2023;40(11):989-992
- CountryChina
- Language:Chinese
- Abstract: Objective To explore the effects of valproate on vestibular migraine （VM） symptom improvement and vestibular function. Methods The patients with VM treated in the Dizziness Diagnosis and Treatment Center of The Second Affiliated Hospital of Naval Medical University from September 1，2019 to May 1，2021 were randomly divided into Valproate group and Flunarizine group. The patients were treated with valproate or flunarizine for three months. Before and after the treatment，the frequency of VM as well as the scores of Visual Analogue Scale （VAS） and Dizziness Handicap Inventory （DHI） items were recorded. Vestibular function was compared in the Valproate group before and after treatment. Results The VM frequency，the total scores of VAS and DHI，and the scores of VAS and DHI items in both groups were significantly reduced after the treatment. The changes in VM frequency，VAS score，DHI-F score，DHI-P score，and total DHI score before and after treatment were significantly greater in the Valproate group than in the Flunarizine group. There was no significant difference in the variation of DHI-E score before and after treatment between the two groups. Abnormal eye movement，gaze，and spontaneous nystagmus decreased significantly in the Valproate group after treatment. There were no significant differences in abnormal caloric test，c-VEMP，o-VEMP，saccade test，smooth pursuit test，and direction-changing positional nystagmus. Conclusion Valproate can significantly improve the symptoms of VM and reduce its frequency. Valproate is more efficient than flunarizine.
- Full text:202406131925233407Effects of valproate on vestibular migraine symptom improvement and vestibular function.pdf
