Causal relationship between gut microbiota and vestibular dysfunction： a mendelian randomization study
- VernacularTitle:肠道微生物和前庭功能障碍之间的因果关系：孟德尔随机化研究
- Author:
Bin ZHANG
1
;
Li SUN
1
Author Information
- Publication Type:Journal Article
- Keywords: Mendelian randomization; Gut microbiota; Vestibular dysfunction; Causal relationship
- From: Journal of Apoplexy and Nervous Diseases 2023;40(11):983-988
- CountryChina
- Language:Chinese
- Abstract: Objective Previous research has indicated a discernible association between gut microbiota and vestibular dysfunction； however，further investigation is required to establish a causal relationship. This study aims to comprehensively study the causal relationship between gut microbiota and vestibular dysfunction and determine the species of related gut microbes. Methods A two-sample Mendelian randomization analysis was performed. The gut microbiome data of 18 340 individuals obtained from the genome-wide association study （GWAS） by the MiBioGen consortium in 2021 were used as the exposure samples. The GWAS data related to vestibular dysfunction were used as the outcome samples. The inverse variance weighting method was employed to analyze the gut microbiome data. The results were assessed based on the odds ratio（OR）as the effect index with 95% confidence interval（CI）. The stability and reliability of the findings were assessed using the leave-one-out，heterogeneity，horizontal pleiotropy，and false discovery rate approaches. Results The results indicated a significant association between an elevated abundance of Bifidobacterium and a decreased risk of vestibular dysfunction. Furthermore，the leave-one-out method confirmed the stability of the results and the absence of instrumental variables exerting substantial influence on the findings. The causal relationship was negative. The influence of heterogeneity and horizontal pleiotropy on the causal effect could be eliminated. Conclusion Bifidobacterium may affect vestibular dysfunction by influencing 5-HT through the “gut-brain axis”，but this result still needs further verification.
- Full text:2024061319223746548肠道微生物和前庭功能障碍之间的因果关系_孟德尔随机化研究.pdf
