Epidemiological characteristics and genotype of norovirus outbreaks in schools in Xicheng District of Beijing from 2017 to 2022
10.16835/j.cnki.1000-9817.2024155
- VernacularTitle:北京市西城区2017—2022年学校诺如病毒 疫情流行特征及基因分型
- Author:
LIU Xiaoxiao, HUANG Yanhong, CHU Yanhui, SUN Jingyi, YANG Xiong, KONG Qingzheng, JI Yanli, GAO Zhiyong
1
Author Information
1. Department of Infectious Disease and Endemic Disease Control, Xicheng District Center for Disease Prevention and Control, Beijing (100120) , China
- Publication Type:Journal Article
- Keywords:
Enterovirus infections;
Disease outbreaks;
Genes;
Incidence;
Student health services
- From:
Chinese Journal of School Health
2024;45(5):704-707
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the epidemiological and molecular characteristics of norovirus outbreaks in schools in Xicheng District of Beijing from 2017 to 2022, so as to provide evidence for the prevention and control of norovirus outbreaks in schools.
Methods:Data of norovirus outbreaks in schools in Xicheng District, Beijing during 2017 to 2022 were collected and analyzed by descriptive epidemiological methods. Realtime PCR was used to detect the nucleic acid of group GⅠand GⅡnorovirus, the positive norovirus nucleic acid samples were sent to Beijing Center for Disease Control and Prevention for molecular typing.
Results:From 2017 to 2022, 185 norovirus outbreaks were reported in schools in Xicheng District, including 166 cluster outbreaks and 19 outbreaks. A total of 2 044 cases were reported, with a total attack rate of 13.92%. There were two peaks in the outbreak time, which were from March to June after the spring semester and from October to December after autumn semester. Primary schools were the most common place of occurrence (101 cases), followed by nursery institutions (68 cases) and secondary schools (16 cases). There were statistically significant differences in the incidence rates among different sites(12.37%, 22.78%, 8.47%, χ2=263.34, P<0.01). There were significant differences in the incidence of vomiting, diarrhea, nausea and stomachache among different students (χ2=263.33, 90.58, 20.42, 30.29, P<0.01). Vomiting was the main symptom in primary school and nursery school children (96.41%, 98.28%), and the diarrhea rate was higher in middle school students (68.22%). The outbreaks were mainly caused by type GⅡ norovirus. The genotype from 2017 to 2021 showed the characteristics of diversity, mainly GⅡ.2[P16], but there was no significant advantage for the GⅡ.2 [P16] during 2019 to 2021.
Conclusions:The norovirus outbreak in schools in Xicheng district of Beijing from 2017 to 2022 are mainly caused by GⅡ type genome. The main genotype is GⅡ.2[P16]. Norovirus infection mainly occurred in primary schools and kindergartens. For the vulnerable populations, it is necessary to improve the capacity to early identification, student infectious disease management, active infection control and prevention measures, and pathogen surveillance and sporadic case monitoring.
