Paraneoplastic neurological syndrome with positive SOX-1， GABABR， and VGCC antibodies： A case report and literature review
- VernacularTitle:抗SOX-1，GABABR和VGCC抗体阳性的副肿瘤综合征：病例报告与文献回顾
- Author:
Li ZHOU
1
;
Yansheng DING
1
Author Information
- Publication Type:Journal Article
- Keywords: Paraneoplastic neurological syndrome; Anti-SOX1 antibody; Anti-GABABR antibody; Anti-P/Q-type VGCC antibody; Small cell lung cancer
- From: Journal of Apoplexy and Nervous Diseases 2023;40(12):1114-1118
- CountryChina
- Language:Chinese
- Abstract: Objective Paraneoplastic neurological syndrome is a rare immune-mediated disease induced by underlying tumors， and early identification of special subtypes of paraneoplastic syndrome and specific autoantibodies can guide efficient tumor screening， thereby promoting timely antitumor treatment and prolonging survival time. Methods A retrospective analysis was performed for the diagnosis and treatment of a case of paraneoplastic neurological syndrome with multiple clinical phenotypes and multiple autoantibodies who was admittd to Department of Neurology， Weifang People’s Hospital， and a systmatical review was performed for related articles. Results The patient presented with unsteady gait and mental and behavioral disorders in the early stage and was initially diagnosed with paraneoplastic cerebellar degeneration and paraneoplastic limbic encephalitis with positive anti-SOX-1 and anti-GABABR antibodies. Due to abnormal electrophysiological results and positive P/Q-type VGCC antibodies， the patient was considered to have Lambert-Eaton myasthenic syndrome， and all evidence suggested that the patient had occult small cell lung cancer. Finally thoracoscopic biopsy confirmed that lymph node enlargement on PET-CT was in accordance with the pathological changes of small cell lung cancer. The patient received both antitumor treatment and immunotherapy and had a survival time of 19 months. Conclusion The detection of anti-SOX1 antibodies should promote the screening for small cell lung cancer. In patients with paraneoplastic limbic encephalitis and paraneoplastic neuromuscular syndromes mediated by cell surface antibodies， immunotherapy should be initiated in parallel with antitumor treatment， and such patients tend to have a good prognosis.
- Full text:2024061222062613477抗SOX-1,GABABR...综合征：病例报告与文献回顾_周丽.pdf
