Gender differences with carotid atherosclerotic plaque： a metabolomic study based on UPLC-MS
- VernacularTitle:性别差异与颈动脉粥样硬化斑块：基于UPLC-MS技术的代谢组学研究
- Author:
Tian YU
1
;
Rui LIU
1
Author Information
- Publication Type:Journal Article
- Keywords: Carotid atherosclerotic plaque; Metabolomics; Male; Female
- From: Journal of Apoplexy and Nervous Diseases 2023;40(12):1108-1113
- CountryChina
- Language:Chinese
- Abstract: Objective The purpose of this study is to explore the differences of urine metabolites in carotid atherosclerotic plaque patients of different sexes， explore the different pathogenesis of carotid atherosclerotic plaque in men and women， and try to explain the biological differences caused by gender. Methods Urine of 28 men and 14 women with carotid atherosclerotic plaque were collected and analyzed by ultraperformance liquid chromatography mass spectrometry （UPLC-MS）. Perform metabolomics data analysis based on the Metaboanalysis website to identify differential metabolites between male and female patients. In order to further understand the function of metabolites， biological function and pathway enrichment analysis were conducted on metabolites. Results There were significant differences in the expression of 34 metabolites in the urine of patients with carotid atherosclerotic plaque of different sexes. The functions of these metabolites are mainly enriched in histidine metabolism，β-Alanine metabolism， arginine biosynthesis，pantothenate and coenzyme A biosynthesis，and glutathione metabolism pathways. Conclusion There are significant differences in urine metabolic profiles between male and female patients with carotid atherosclerotic plaque.
- Full text:2024061221544025173性别差异与颈动脉粥样硬化斑块_基于UPLC-MS技术的代谢组学研究.pdf
