Research on the role of resveratrol against breast cancer
- VernacularTitle:白藜芦醇抗乳腺癌的研究进展
- Author:
Qingdong GAO
1
;
Xufang DUAN
2
;
Yan LI
3
;
Tao XU
1
;
Yangyang YU
1
;
Guodong BAI
4
Author Information
1. Dept. of Pharmacy，Jiamusi Hospital of TCM，Heilongjiang Jiamusi 154002，China
2. Dept. of Pharmacy，Jiamusi Xiangyang District People’s Hospital，Heilongjiang Jiamusi 154002，China
3. Dept. of Pharmacy，the Fourth Affiliated Hospital of Heilongjiang University of TCM，Harbin 150006，China
4. Preparation Room，Jiamusi Hospital of TCM，Heilongjiang Jiamusi 154002，China
- Publication Type:Journal Article
- Keywords:
resveratrol;
breast cancer;
cell apoptosis;
autophagy;
glycolysis;
tumor microenvironment;
cell invasion;
cell
- From:
China Pharmacy
2024;35(11):1408-1412
- CountryChina
- Language:Chinese
-
Abstract:
Breast cancer （BC） ranks first in the incidence rate of female malignant tumor， the notable features of which include high invasive behavior， high malignant degree and poor prognosis. Resveratrol， a plant antioxidant， has been identified as a potential therapeutic agent for the occurrence and progress of BC. This article explores the mechanism of resveratrol intervention in BC by evaluating several in vitro and in vivo studies. It was found that resveratrol can weaken the proliferation and survival ability of BC cells， suppress their growth， metastasis， and invasion， and reverse their resistance to adriamycin by promoting cell apoptosis， regulating autophagy， inhibiting glycolysis and regulating the tumor microenvironment， expressions of matrix metalloproteinases， epithelial-mesenchymal transition and drug-resistant proteins， etc. The limited number of clinical trial studies on resveratrol， mainly focusing on prevention effect of it on breast cancer， may be one of the reasons that affect the comprehensive evaluation of the anti-cancer efficacy of resveratrol.
