Research progress on the chemical components anti-tumor effects and preparations of zedoary turmeric oil
- VernacularTitle:莪术油化学成分、抗肿瘤作用及制剂研究进展
- Author:
Tianqi HUA
1
,
2
;
Yuling LIU
2
;
Longfei LIN
2
;
Qian LIAO
2
;
Hui LI
2
Author Information
1. Academician Workstation，Jiangxi University of Traditional Chinese Medicine，Nanchang 330004，China
2. Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences，Beijing 100700，China
- Publication Type:Journal Article
- Keywords:
zedoary turmeric oil;
chemical components;
anti-tumor;
preparation
- From:
China Pharmacy
2024;35(11):1396-1402
- CountryChina
- Language:Chinese
-
Abstract:
Zedoary turmeric oil， volatile oil extracted from zedoary turmeric， composed mainly of monoterpenes （including α-pinene， β-pinene， etc.） and sesquiterpenes （including β-elemene， zedoary alcohol， zedoary ketone， etc.）， and has been used in clinical practice to treat various malignant tumors such as ovarian cancer， cervical carcinoma， colorectal cancer， lung cancer and liver cancer. Zedoary turmeric oil regulates vascular endothelial growth factor and nuclear factors- κB， signal transducers and activator of transcription 3 signaling pathways to play a role in inhibiting tumor angiogenesis， inhibiting tumor cell proliferation， inducing tumor cell apoptosis， and blocking cell cycle. However， due to its insolubility in water and poor stability， its clinical application is limited； the application of new formulations and technologies such as liposomes， microspheres， and nanoemulsion improves the solubility and stability of zedoary turmeric oil. This paper summarizes recent research progress on the chemical composition， anti-tumor effects， and formulations of zedoary turmeric oil， both domestically and internationally， providing a reference for further expanding the clinical application and formulation development of zedoary turmeric oil in the anti-tumor field.
