Mechanism research progress of traditional Chinese medicine intervening in lung cancer by regulating p53 signaling pathway
- VernacularTitle:中药调控p53信号通路干预肺癌的作用机制研究进展
- Author:
Qian MA
1
,
2
;
Ya LI
1
,
2
;
Yizhao MA
1
,
2
;
Kai CHEN
1
,
2
;
Yuanyuan WANG
1
,
2
,
3
;
Hailong ZHANG
1
,
2
Author Information
1. Dept. of Respiratory and Critical Care Medicine，the First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450003，China
2. First College of Clinical Medicine，Henan University of Chinese Medicine，Zhengzhou 450003，China
3. Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases Co-constructed by Henan Province & Education Ministry of P. R. China/Henan Key Laboratory of Chinese Medicine for Respiratory Disease，Henan University of Chinese Medicine，Zhengzhou 450046，China
- Publication Type:Journal Article
- Keywords:
lung cancer;
p53 signaling pathway;
mechanism;
traditional Chinese medicine;
effective components
- From:
China Pharmacy
2024;35(11):1403-1407
- CountryChina
- Language:Chinese
-
Abstract:
Lung cancer， the most common malignant tumor， is characterized by a complex pathogenesis and high malignancy， and poses a significant threat to the health and lives of affected individuals. p53 signaling pathway plays a crucial role in the progression of lung cancer and is considered one of the potential targets for targeted therapy. In recent years， multiple studies have indicated that traditional Chinese medicine （TCM） can exert anticancer effects by modulating the p53 signaling pathway. Based on this， this article systematically summarizes the current status and progress of research on TCM intervening in lung cancer by regulating p53 signaling pathway. It was found that TCM formula and preparations， such as Qingjin desheng tablet， Tiaoqi xiaoji decoction， Bufei tongluo jiedu formula， Jianpi bushen formula and Yiqi fuzheng jiedu formula， can promote autophagy and apoptosis of lung cancer cells， inhibit the growth and metastasis of lung cancer cells and strengthen the immune function of the body by activating p53 signaling pathway， thereby inhibiting lung cancer. TCM monomers， such as pseudoginsenoside-Rh2， saikosaponin D， polyphyllin Ⅶ， dendrobiine， sophoridine， gambogic acid， triptolide and triptolide succinate monoester YJ-4， can accelerate cell apoptosis， inhibit the proliferation of lung cancer cells and regulate cell cycle by activating p53 signaling pathway， thereby inhibiting lung cancer.
