Effects of body mass index and serum lipid levels on prostate volume in patients with benign prostatic hyperplasia
10.3969/j.issn.1009-8291.2024.02.004
- VernacularTitle:身体质量指数和血脂对良性前列腺增生患者前列腺体积的影响
- Author:
Aibo PANG
1
;
Jungang LYU
2
;
Cunbao LING
1
;
Tongshuo ZHANG
3
;
Chunyan ZHANG
1
;
Yaping TIAN
1
Author Information
1. Birth Defects Prevention and Control Technology Research Center, Medical Research and Innovation Department, Chinese PLA General Hospital, Beijing 100853
2. The Third Department of Internal Medicine, Beijing Corps Hospital of Chinese People’s Armed Police Force, Beijing 100027
3. Department of Clinical Laboratory and Pathology, Jiangsu Provincial Corps Hospital of Chinese People’s Armed Police Force, Yangzhou 225003, China
- Publication Type:Journal Article
- Keywords:
benign prostatic hyperplasia;
prostate volume;
body mass index;
apolipoprotein B
- From:
Journal of Modern Urology
2024;29(2):114-118
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To explore the correlation between body mass index (BMI) and lipid indexes with prostate volume in patients with benign prostatic hyperplasia (BPH) so as to provide reference for the clinical prevention of this disease. 【Methods】 Clinical data of 578 patients admitted to the Department of Urology of Chinese PLA General Hospital during Jan.2014 and Dec.2022 were collected.The patients underwent initial prostate puncture biopsy or prostatectomy and BPH was confirmed pathologically.The patients’ age, time of onset of the disease, BMI, past medical history and biochemical indexes were analyzed.According to the total prostate volume (TPV) grading, the patients were divided into TPV>75 mL and TPV≤75 mL groups.The general data of the two groups were compared, and predictors of TPV were determined with linear regression analysis.The samples were stratified with BMI to observe the differences in the effects of apolipoprotein B (ApoB) on TPV. 【Results】 There were 215 cases in the TPV>75 mL group and 363 cases in the TPV≤75 mL group.The levels of BMI, triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and apolipoprotein B (ApoB) were higher in the TPV>75 mL group (P<0.01).Multivariate linear regression analysis showed that age (β=0.604, P=0.003), BMI (β=2.000, P<0.001), ApoB (β=23.792, P<0.001) and TPV had a significant positive linear correlation; after adjusting for the confounders of age and BMI, ApoB was not linearly correlated with TPV in BPH population with BMI<24 (P>0.05), and ApoB predicted prostate volume growth in overweight and obese BPH population respectively (β=26.411, P=0.011; β=47.602, P=0.017). 【Conclusion】 Age, ApoB and BMI can be used as predictors of volume growth in BPH patients, which can help further research on the pathogenesis and progression of BPH.
