Safety of modified radical prostatectomy by transperineal injection of sodium hyaluronate to the Dirichlet gap: an animal experiment
10.3969/j.issn.1009-8291.2024.03.013
- VernacularTitle:经会阴穿刺注射玻璃酸钠扩张狄氏间隙改良前列腺根治性切除术安全性的动物实验
- Author:
Jinbang WU
1
;
Bo ZHU
1
;
Weidong CHEN
1
;
Fei CHEN
1
;
Chunhong FAN
1
;
Tingting YU
1
;
Taotao DONG
2
,
3
;
Xun LIU
2
,
3
;
Yunhan WANG
2
;
Zili WANG
2
Author Information
1. Department of Urology, Deyang Fifth Hospital, Deyang 618099
2. Department of Urology, Affiliated Hospital of Chengdu University, Chengdu 610081
3. Central Laboratory, Affiliated Hospital of Chengdu University, Chengdu 610081, China
- Publication Type:Journal Article
- Keywords:
prostate cancer;
rectal injury;
Dirichlet gap;
sodium hyaluronate;
laparoscope;
animal experiment;
radical prostatectomy;
safety of surgery
- From:
Journal of Modern Urology
2024;29(3):268-272
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To explore the safety of transrectal ultrasound-guided transperineal injection of sodium hyaluronate to expand the Dirichlet gap in laparoscopic radical prostatectomy. 【Methods】 A total of 14 healthy male purebred beagle dogs were selected and randomly divided into 2 groups, with 7 in either group.The control group was treated with conventional laparoscopic radical prostatectomy, while the experimental group was treated with laparoscopic radical prostatectomy after 2.5 mL sodium hyaluronate was injected into the Dirichlet gap under the guidance of transrectal ultrasound.The total operation time, prostate separation time, intraoperative blood loss and rectal status of the 2 groups were observed. 【Results】 After the injection of sodium hyaluronate into the Dirichlet gap between the prostate and the rectum, no rectal tissue was found in the prostate, and no obvious damage was found in the posterior rectum in either groups.The postoperative hemoglobin (HGB) was [(118.70±2.56) g/L vs.(122.10±2.19) g/L, P=0.02]; the total operation time was [(141.40±9.80) min vs.(119.10±9.16) min, P<0.05]; the prostate separation time was [(24.99±1.75) min vs.(16.64±2.34) min, P<0.05]; the amount of bleeding was [(47.43±4.32) mL vs.(34.86±5.18) mL, P<0.05] in the control group and experimental group. 【Conclusion】 Laparoscopic radical prostatectomy performed after 2.5 mL of sodium hyaluronate injection into the Dirichlet gap under the guidance of transrectal ultrasound can shorten the total operation time, the separation and resection time of the prostate, and reduce the amount of bleeding, which can improve and reduce the incidence of rectal injury, and prove the feasibility of this approach for prostatic cancer.
