Analysis of the expression and clinical significance of prostate cancer tissue-specific lncRNAs based on bioinformatics databases
10.3969/j.issn.1009-8291.2024.03.007
- VernacularTitle:基于生物信息数据库分析前列腺癌组织特异性lncRNA表达及临床意义
- Author:
Pingzhou CHEN
1
;
Qingjiang XU
1
;
Huang LIN
1
;
Xiang HUANG
2
;
Xiang WU
1
Author Information
1. Department of Urology, Fujian Provincial Hospital, Fuzhou 350004
2. Department of Urology, Nanping First Hospital Affiliated to Fujian Medical University, Nanping 353000, China
- Publication Type:Journal Article
- Keywords:
prostate cancer;
bioinformatics;
lncRNA;
PCAT14;
PCA3
- From:
Journal of Modern Urology
2024;29(3):232-237
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To explore the expression and clinical significance of prostate cancer tissue-specific lncRNAs. 【Methods】 The gene differences of 492 prostate cancer tissues and 152 adjacent tissues in TCGA and GEO genomic databases were analyzed with bioinformatics methods. A total of 5 lncRNAs were screened out, and their specificity in prostate tissues and impact on the prognosis of patients were analyzed. 【Results】 The 5 lncRNAs included PCAT14, PCA3, CTBP1-AS, DRAIC, and GPC5-AS1. PCAT14 and PCA3 were specifically expressed in prostate cancer tissues, and elevated expression was related to the prognosis. Moreover, they were well correlated with prostate cancer-specific antigens such as KLK3, AMACR, SLC45A3, and so on. GO function enrichment analysis and KEGG pathway enrichment analysis showed that the differential expression of PCA3 was closely related to phagocytosis, cell recognition, defense response to bacteria, immunoglobulin complex, Golgi apparatus, antigen binding, chemokine receptor binding, white matter digestion and absorption, renin-angiotensin system and other signaling pathways, while the differential expression of PCAT14 was closely related to the activity of Golgi apparatus and ion channels, renin secretion, cAMP signaling pathway, and gonadotropin secretion-related signaling pathway. 【Conclusion】 PCA3 and PCAT14 are specifically expressed in prostate cancer tissues, not in normal tissues, which can be used as potential indicators for the diagnosis of prostate cancer.
