Nephrolithotomy in patients with complex kidney calculi
10.3969/j.issn.1009-8291.2024.04.011
- VernacularTitle:血清HBD-3、DCR3对复杂性肾结石患者经皮肾镜碎石术后尿路感染的预测价值
- Author:
Feng WEI
1
;
Guangjun ZHOU
1
;
Shuanghui LI
1
;
Yanyan WANG
1
;
Zhijie JI
1
Author Information
1. Department of Urology, Cangzhou Hospital of Integrated Traditional and Western Medicine, Cangzhou 061000, China
- Publication Type:Journal Article
- Keywords:
complex kidney calculi;
percutaneous nephrolithotomy;
β-defensin-3;
trick receptor 3;
urinary tract infection;
C reactive protein;
procalcitonin
- From:
Journal of Modern Urology
2024;29(4):342-346
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To analyze the predictive value of serum β-defensin-3 (HBD-3) and decoy receptor 3 (DCR3) for urinary tract infection after percutaneous nephrolithotomy (PCNL) in patients with complex kidney calculi. 【Methods】 A prospective study was conducted on 112 patients treated with PCNL at our hospital during Jan.2020 and Dec.2022.The patients were divided into the non-infection group (52 cases) and infection group (60 cases).The general data, HBD-3 and DCR3 levels of the two groups were compared.Receiver operating characteristic (ROC) curve was drawn to analyze the predictive value of C reactive protein (CRP), procalcitonin (PCT), HBD-3 and DCR3 levels for postoperative urinary tract infection. 【Results】 Compared with the non-infection group, the infection group had higher levels of HBD-3 [(0.77±0.08) ng/mL vs. (1.36±0.25) ng/mL, P=0.001] and DCR3 [(4.68±0.53) ng/mL vs.(13.21±0.28) ng/mL, P=0.001].Multivariate logistic regression showed that a history of urinary tract surgery, preoperative urinary tract infection, operation time, catheterization time, stone load, type of antibiotics, concomitant renal dysfunction, intraoperative channel type, CRP, PCT, HBD-3 and DCR3 were risk factors of postoperative urinary tract infection (P<0.05).The ROC curve showed that the accuracy of CRP, PCT, and CRP plus PCT were 70.54%, 72.32%, and 78.57%, respectively; the accuracy of HBD-3, DCR3, and HBD-3 plus DCR3 were 69.64%, 75.89%, and 86.61%, respectively. 【Conclusion】 Postoperative urinary tract infection in patients with complex kidney calculi is associated with multiple factors, especially high expression levels of HBD-3 and DCR3.Combined detection has high predictive value.
