Prognosis of 233 advanced renal cell carcinoma patients in Urumqi: a two-center study
10.3969/j.issn.1009-8291.2024.04.004
- VernacularTitle:新疆乌鲁木齐市双中心233例晚期肾细胞癌患者的预后分析
- Author:
Dilixiati DILIYAER
1
;
Shuai YUAN
2
;
Jiande LU
1
;
Bingzhang QIAO
1
;
Wenguang WANG
1
;
Peng CHEN
2
;
Rexiati MULATI
1
;
Azhati BAIHETIYA
1
Author Information
1. Department of Urology, The First Affiliated Hospital of Xinjiang Medical University, Xinjiang Clinical Medical Research Center of Urogenital Diseases, Urumqi 830054, China
2. Department of Urology, The Affiliated Cancer Hospital of Xinjiang Medical University, Urumqi 830054, China
- Publication Type:Journal Article
- Keywords:
renal cell carcinoma;
distant metastasis;
clinical characteristics;
prognosis;
IMDC;
Xinjiang
- From:
Journal of Modern Urology
2024;29(4):306-311
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To investigate the clinical features, treatment methods and prognosis of advanced renal cell carcinoma (RCC) patients in Xinjiang, especially the Han population. 【Methods】 Clinical data of 233 patients with advanced RCC treated in The First Affiliated Hospital and The Affiliated Cancer Hospital of Xinjiang Medical University were retrospectively analyzed, including 133 Han patients.The median age of patients was 52 years (range: 23 to 87), and the maximum tumor diameter was (7.73±4.04) cm.Survival curves were plotted using the Kaplan-Meier method.Multivariate and univariate Cox regression analysis were conducted for all patients, and further analysis was performed for the Han patients. 【Results】 Among the 233 patients, 131 died during the average follow-up of 27.6 months (range: 1 to 120), and the median survival time was 12 months.In this cohort, 110 patients had lymph node metastasis, and 200 had distant metastasis, among them, 21 (10.5%) patients had brain metastasis and 45 (22.5%) patients had adrenal metastasis.The 1-, 3-, and 5-year survival rate were 48.9%, 18.3% and 6.1%, respectively.Univariate analysis revealed that International mRCC Database Consortium (IMDC) score, pathological type, lymph node metastasis, distant metastasis, number of metastatic foci and treatment methods impacted the prognosis in Xinjian (P<0.05).Multivariate analysis indicated that IMDC score, pathological type and distant metastasis were significant factors influencing the prognosis, which were also the prognostic factors of the Han patients (P<0.05). 【Conclusion】 In Xinjiang, patients with advanced renal cell carcinoma have a 6.1% 5-year survival rate and a median survival time of 12 months.Brain and adrenal metastases are common.Prognostic factors include IMDC score, pathological type, and distant metastasis for all patients, including the Han patients.
