Two-sample bidirectional Mendelian randomization for analyzing the causal effect between gastroesophageal reflux disease and migraine headaches

Jiaxin MA; Yuanzhi Zhou; Wenwen Chen; Yahan Zhao; Xu Zhang; Yarui LI; Shuixiang HE; Yan Zhao

Return

Two-sample bidirectional Mendelian randomization for analyzing the causal effect between gastroesophageal reflux disease and migraine headaches

VernacularTitle:两样本双向孟德尔随机化分析胃食管反流病与偏头痛间的因果效应
Author: Jiaxin MA ^{1
,

2} ; Yuanzhi ZHOU ^{1
,

2} ; Wenwen CHEN ^{1
,

2} ; Yahan ZHAO ^{1
,

2} ; Xu ZHANG ^{1
,

2} ; Yarui LI ^{1
,

2} ; Shuixiang HE ^{1
,

2} ; Yan ZHAO ^{1
,

2}
Author Information

1. Department of Gastroenterology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061
2. Clinical Medical Research Center for Digestive Diseases of Shaanxi Province (Oncology), Xi’an 710061, China
Publication Type:Journal Article
Keywords: gastroesophageal reflux disease; migraine; Mendelian randomization; causal relationship; risk factor
From: Journal of Xi'an Jiaotong University(Medical Sciences) 2024;45(2):262-270
CountryChina
Language:Chinese
Abstract: 【Objective】 To explore the causal association between the onset of gastroesophageal reflux disease (GERD) and migraine and to provide genetic evidence, a two-sample bidirectional Mendelian randomization (MR) method was used in this study. 【Methods】 Single nucleotide polymorphism (SNP) information for both samples was obtained from publicly available genome-wide association study (GWAS) databases, in which the appropriate SNPs were selected as instrumental variables, and then bidirectional MR analysis used five MR analysis methods including inverse variance weighting (IVW), MR-Egger regression, weighted median, weighted mode and simple mode methods, followed by sensitivity analysis. 【Results】 IVW showed positive results of forward MR analysis with GERD as exposure [OR=1.398 7, 95%CI (1.181 7-1.655 6), P=9.59×10^-5] , while no positive significance of reverse MR analysis results with migraine as exposure (P>0.05). The same results were obtained in methods other than MR-Egger method. Meanwhile, none of the instrumental variables were found to be horizontally polytomous (P=0.92, P=0.64), and the results were robust after the leave-one-out method to exclude single SNPs. 【Conclusion】 There may be a unidirectional causal association between GERD and migraine, and GERD is a risk factor for migraine development.