Associations of genetic variants in GLP-1R with blood pressure responses to dietary sodium and potassium interventions

Mingke Chang; Chao Chu; Mingfei DU; Hao Jia; Yue Sun; Guilin HU; Xi Zhang; Dan Wang; Wenjing Luo; Yu Yan; Ziyue Man; Yang Wang; Jianjun MU

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Associations of genetic variants in GLP-1R with blood pressure responses to dietary sodium and potassium interventions

VernacularTitle:GLP-1R基因多态性与血压钠钾反应性的相关性分析
Author: Mingke CHANG ¹ ; Chao CHU ¹ ; Mingfei DU ¹ ; Hao JIA ¹ ; Yue SUN ¹ ; Guilin HU ¹ ; Xi ZHANG ¹ ; Dan WANG ¹ ; Wenjing LUO ¹ ; Yu YAN ¹ ; Ziyue MAN ¹ ; Yang WANG ¹ ; Jianjun MU ¹
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1. Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China
Publication Type:Journal Article
Keywords: glucagon-like peptide-1 receptor (GLP-1R); gene polymorphism; salt sensitivity; salt; potassium; hypertension
From: Journal of Xi'an Jiaotong University(Medical Sciences) 2024;45(2):212-218
CountryChina
Language:Chinese
Abstract: 【Objective】 To investigate the association between genetic variations in the glucagon-like peptide-1 receptor (GLP-1R) gene and BP responses to sodium and potassium intake. 【Methods】 A total of 514 subjects from 124 families were recruited in Meixian County, Shaanxi Province, in 2004, resulting in the establishment of a "salt-sensitive hypertension study cohort" . The subjects followed a dietary regimen which involved a normal diet for 3 days, a low-salt diet for 7 days, a high-salt diet for 7 days, and a high-salt potassium-supplemented diet for 7 days. BP measurement was conducted at different intervention periods, and peripheral blood samples were collected. Additionally, eight single nucleotide polymorphisms (SNPs) of the GLP-1R gene were genotyped using the MassARRAY detection platform. 【Results】 The GLP-1R gene SNP rs9462472 exhibited a significant association with systolic BP, diastolic BP, and mean arterial pressure response to high-salt intervention. Similarly, SNP rs2268637 showed a significant association with systolic BP response to high-salt intervention. Furthermore, SNP rs2268637 was significantly associated with systolic BP and mean arterial pressure responses to high-salt plus potassium supplementation intervention. 【Conclusion】 Our findings indicate a significant association of genetic variations in the GLP-1R gene with BP responses to sodium and potassium intake. This suggests that the GLP-1R gene plays a role in the regulation of BP salt sensitivity and potassium sensitivity.