Causal relationship between educational attainment and pancreatitis: a Mendelian randomization study
- VernacularTitle:受教育程度与胰腺炎的因果关系：一项孟德尔随机化研究
- Author:
Ruiqi CAO
1
,
2
;
Zhengyuan FENG
1
,
2
;
Jiaoxing WU
1
,
2
;
Jie LI
1
,
2
;
Zheng WANG
1
,
2
;
Zheng WU
1
,
2
;
Cancan ZHOU
1
,
2
Author Information
- Publication Type:Journal Article
- Keywords: pancreatitis; educational attainment (EA); Mendelian randomization (MR); genome-wide association study (GWAS); risk factor
- From: Journal of Xi'an Jiaotong University(Medical Sciences) 2024;45(2):200-205
- CountryChina
- Language:Chinese
- Abstract: 【Objective】 To explore the causal relationship between education level and pancreatitis risk through Mendelian randomization. 【Methods】 A two-sample Mendelian randomization analysis was conducted using genome-wide association study (GWAS) summary data. The GWAS data for education level and pancreatitis were obtained from SSGAC database and the FinnGen database (version R9). Causal relationship between education level and pancreatitis was explored using the inverse variance weighted (IVW), MR-Egger, and weighted median methods. Heterogeneity and directional pleiotropy were evaluated using Cochran’s Q test and funnel plots. 【Results】 Totally 604 SNPs associated with education level were included. The results provided evidence that there was negative relationship between education level and pancreatitis risk. For acute pancreatitis, OR=0.52, 95% CI: 0.44-0.62, P=2.43×10-14 while for chronic pancreatitis, OR=0.51, 95% CI: 0.41-0.64, P=7.20×10-9. Results from MR-Egger and weighted median analyses obtained the same results. The results of sensitivity analysis indicated that this study did not violate the basic assumptions of Mendelian randomization. 【Conclusion】 There is a causal relationship between education level and the occurrence of pancreatitis. The educational level is negatively correlated with the risk of pancreatitis.
