Equipment for screening and analysis of target substances in the complex system of traditional Chinese medicine based on cell membrane chromatography technology
10.7652/jdyxb202403001
- VernacularTitle:基于细胞膜色谱技术的中药复杂体系目标物筛选分析装备
- Author:
Langchong HE
1
;
Huaizhen HE
;
Shengli HAN
;
Tao ZHANG
;
Cheng WANG
;
Weina MA
Author Information
1. 西安交通大学药学院,陕西西安 710061
- Keywords:
cell membrane chromatography(CMC);
traditional Chinese medicine;
screening;
analysis equipment
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2024;45(3):351-359
- CountryChina
- Language:Chinese
-
Abstract:
Traditional Chinese medicine(TCM)is extensively utilized for clinical disease prevention and treatment.However,due to the intricate nature of its material basis and the multiple factors involved in the preparation process,ensuring comprehensive quality control of TCM proves to be challenging.By instilling a clear understanding of its effective and harmful substances and implementing control over the content and limit of TCM during the preparation process,the controllability and repeatability of its quality can be guaranteed.Currently,China is facing a dearth of innovative technology for drug development,necessitating an increase in research and development efficiency,especially in the realm of high-throughput precision analytical equipment.The country has long relied on imported pharmaceutical analysis equipment with a particular efficiency in high-end intelligent analysis equipment.This is especially concerning considering the urgent requirement to establish a"pharmaceutical intelligent analysis system."This project,supported by the Major Instrument Development Project of the National Science and Technology Funds,employs cell membrane chromatography technology,complemented by biotechnology and artificial intelligence technology,to devise a two-dimensional cell membrane chromatography(2D/CMC)analyzer.The project has successfully conducted a demonstration application of the"2D/CMC-Traditional Chinese Medicine Pharmacodynamic Substance Analyzer"and the"2D/CMC-Traditional Chinese Medicine Injection Allergen Analyzer".These tools have enhanced the screening and discovery efficiency of TCM's effective substances and allergen components.Moreover,the equipment amalgamates qualitative and quantitative analysis,thereby serving as an effective analytical tool to enhance the quality and efficacy of traditional Chinese medicine.
