Predictive value of preoperative NLR and PLR for inguinal lymph node metastasis of penile cancer
10.3969/j.issn.1009-8291.2024.01.011
- VernacularTitle:术前中性粒细胞与淋巴细胞比值及血小板与淋巴细胞比值对阴茎癌腹股沟淋巴结转移的预测价值
- Author:
Jian LI
1
;
Wenjing GUO
2
;
Zhongzhong SUN
1
;
Jinfeng WU
1
Author Information
1. Department of Urology,The Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan 030032
2. School of Public Health, Shanxi Medical University, Taiyuan 030001, China
- Publication Type:Journal Article
- Keywords:
penile cancer;
inguinal lymph node metastasis;
inflammatory factor;
neutrophis;
lymphocytes;
platelets
- From:
Journal of Modern Urology
2024;29(1):56-59
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To explore the value of preoperative neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in the prediction of inguinal lymph node metastasis of penile cancer to provide a new idea for the clinical evaluation. 【Methods】 A total of 48 patients with penile cancer who received surgical treatment in our hospital during Jan. 2016 and Dec. 2021 were selected and divided into the metastatic group (n=19) and non-metastatic group (n=29). The number of neutrophils, lymphocytes and platelets were recorded, and NLR and PLR were calculated. The value of NLR and PLR in predicting inguinal lymph node metastasis was analyzed with receiver operating characteristic (ROC) curve. The correlation between NLR and PLR was determined with Pearson correlation analysis. 【Results】 The levels of NLR and PLR were significantly higher in the metastatic group than in the non-metastatic group (P<0.05). ROC curve showed that the optimal cut-off value of NLR was 2.39, the area under the ROC curve (AUC) was 0.838 (95%CI:0.730-0.947), with sensitivity of 94.7% and specificity of 58.6%, respectively. The optimal cut-off value of PLR was 113.66, the AUC was 0.755 (95%CI:0.618-0.892), with sensitivity of 89.5% and specificity of 58.6%, respectively. The AUC of the two combined together was 0.851 (95%CI:0.747-0.956), with sensitivity of 89.5% and specificity of 69.0%. The Pearson correlation analysis showed that NLR was positively correlated with PLR in patients in both groups (r=0.504, r=0.645, P<0.05). 【Conclusion】 Preoperative NLR and PLR levels are significantly increased in patients with penile cancer,and the combination of the two indexes can predict the possibility of inguinal lymph node metastasis.
