Analysis of the association between copper death-related genes and prostate cancer
10.3969/j.issn.1009-8291.2024.01.009
- VernacularTitle:铜调节的细胞死亡相关基因与前列腺癌关系分析
- Author:
Wei LI
1
;
Feng CHENG
1
;
Junlei ZHU
1
;
Suogang WANG
1
Author Information
1. The First Urology Ward, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450003, China
- Publication Type:Journal Article
- Keywords:
prostate cancer;
copper-related cell death;
tumor microenvironment;
glycine cleavage system protein H;
cancer genome atlas;
marker
- From:
Journal of Modern Urology
2024;29(1):46-50
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To analyze the association between copper death-related genes and prognosis of prostate cancer and immune cell infiltration based on the cancer genome atlas (TCGA). 【Methods】 The mRNA transcriptome data of all prostate cancer patients were downloaded from TCGA, including 501 prostate cancer tissues and 52 normal tissues.The expression matrix of copper death-related genes was extracted with R software.Differential analysis and multivariate regression analysis were conducted to screen out the prognostic genes, which were then analyzed to explore the correlation between prognosis-related genes and immune cells. 【Results】 GCSH gene was significantly correlated with the prognosis of prostate cancer, and significantly correlated with dendritic cells, CD8+ T cells and plasma cells (P<0.05). 【Conclusion】 GCSH gene plays an important role in the occurrence and development of prostate cancer, and may become a prognostic marker of the disease.
