Risk Factors and Prevention of Late-onset Bacterial Sepsis in Very Preterm Infants
10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).20240419.001
- VernacularTitle:极早产儿晚发型细菌感染败血症的危险因素及防治
- Author:
Guangdong FANG
1
;
Beibei JIA
;
Changchun CHEN
;
Shanyu JIANG
Author Information
1. 江南大学附属妇产医院新生儿科,江苏 无锡 214002
- Keywords:
very preterm infants;
late-onset sepsis;
bacterial infection;
risk factor;
prevention strategy
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2024;45(3):457-465
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To investigate the clinical features and high risk of very preterm infants with late-onset bacteri-al sepsis,so as to propose feasible prevention and treatment suggestions.[Methods]Totally 94 very preterm infants with late-onset bacterial sepsis from the Neonatology Department of Women's Hospital of Jiangnan University were recruited from February,2012 to January,2024.Their clinical data,including the perinatal situation,clinical symptoms,patho-gens,risk factors and treatment,were collected and analyzed.[Results]The incidence rate of very preterm infants with late-onset bacterial sepsis were 8.40 for 100 live birth babies.The major pathogens of the infections among these very pre-mature infants included gram-positive bacteria(71.1%).Logistic regression analysis showed that long term(≥7 d)use of antibiotics,invasive mechanical ventilation,indwelling central venous catheter(≥7 d),and vaginal delivery were high risk factors of very preterm infants with late-onset bacterial sepsis,the relative risk(OR)values were 2.787,4.243,3.033 and 2.174,respectively.[Conclusion]The gram-positive bacteria are the main pathogens of late-onset bacterial sepsis in very preterm infants.Long term(≥7 d)use of antibiotics,invasive mechanical ventilation,indwelling central ve-nous catheter(≥7 d)and vaginal delivery are high risk factors of very preterm infants with late-onset bacterial sepsis.The incidence of late-onset bacterial sepsis in very preterm infants can be reduced by strengthening perinatal management,shortening the time of antibiotic application and reducing invasive operations.
