Correlation Between RC/HDL-C Ratio and Ct-Derived Fractional Flow Reserve in Coronary Heart Disease Patients with Critical Lesions
10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.2024.0314
- VernacularTitle:冠心病临界病变患者残余胆固醇/高密度脂蛋白胆固醇比值水平与冠脉CT血流储备分数的相关性
- Author:
Zhen WU
1
;
Xing SHUI
1
;
Zhen WU
1
;
Zefeng CHEN
1
;
Lin CHEN
1
Author Information
1. Department of Cardiology， The Third Affiliated Hospital of Sun Yat-Sen University， Guangzhou 510630， China
- Publication Type:Journal Article
- Keywords:
critical lesions of coronary heart disease;
computed tomography-derived fractional flow reserve （FFRct）;
RC/HDL-C ratio;
remnant cholesterol （RC）;
lipid metabolism
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2024;45(3):446-456
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the effect of remnant cholesterol （RC）/high-density lipoprotein cholesterol （HDL-C） ratio on coronary computed tomography-derived fractional flow reserve （FFRct） in coronary heart disease （CHD） patients with critical lesions. MethodsA retrospective study was done on patients who were admitted to our department and underwent coronary computed tomography angiography （CCTA） from January 1， 2022 to December 31， 2022. All the 304 culprit vessels from the 219 patients with moderate coronary artery stenosis （50%~70%） were divided into FFRct ischemia group （FFRct≤0.8， N=108） and FFRct non-ischemia group （FFRct>0.8， N=111）. Multivariate logistic regression analysis was used to explore the influencing factors of FFRct≤0.8 in CHD patients with critical lesions. Receiver operating characteristic （ROC） curve was drawn to evaluate the predictive value of RC/HDL-C for FFRct≤0.8. Pearson correlation analysis was used to assess whether there was a correlation between RC/HDL-C and FFRct. ResultsThere were significantly more diabetic patients in FFRct ischemia group （P<0.001）. RC/HDL-C ratio， levels of RC， non-HDL-C， APOB， HbA1c and FPG in FFRct ischemic group were significantly increased （P<0.05）. Pearson correlation analysis showed that the RC/HDL-C ratio， levels of RC， Non-HDL-C， TC， TG， LDL-C， HDL-C， LP（a）， HbA1c， and FPG were all significantly negatively correlated with FFRct values （P<0.05）. Univariate logistic regression analysis showed that diabetes mellitus， RC/HDL-C ratio， levels of RC， non-HDL-C， TG， LP（a）， HbA1c and FPG were significantly correlated with FFRct≤0.8 （P<0.05）. Multivariate logistic regression analysis showed that RC/HDL-C ratio was a predictor of FFRct≤0.80 （OR=4.682， 95%CI 1.197~18.316， P<0.05）. ConclusionsRC/HDL-C ratio is independently correlated with FFRct≤0.8 in CHD patients with moderate stenosis and it is a potential indicator for evaluating coronary functional ischemia.
