Analysis of Depression and Influencing Factors in HIV/AIDS Patients Receiving Antiviral Therapy
10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).20240425.001
- VernacularTitle:抗病毒治疗HIV/AIDS患者抑郁状况及其影响因素分析
- Author:
Xin YUAN
1
,
2
;
Yuanyuan XU
;
Zhengping ZHU
;
Min ZHANG
;
Sushu WU
;
Jingwen WANG
;
Shaokang WANG
Author Information
1. 东南大学公共卫生学院营养与食品卫生学系//环境医学工程教育部重点实验室,江苏 南京 210009
2. 南京市疾病预防控制中心,江苏 南京 210003
- Keywords:
antiviral therapy;
HIV/AIDS patients;
depression;
influencing factor;
logistic regression
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2024;45(3):438-445
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To investigate the depression status and its influencing factors in HIV/AIDS patients receiving antiviral therapy.[Methods]From July 2022 to September 2022,successive sampling method was used to recruit HIV/AIDS patients receiving antiviral therapy from antiviral treatment institutions in Nanjing,and they were instructed to fill out anonymous questionnaires.The questionnaire collected the basic information of patients,and depression,HIV stigma score and social support level were investigated by Patient Health Questionnaire-9(PHQ-9),Berger HIV stigma scale(BHSS)and Multidimensional Scale of Perceived Social Support(MSPSS).Multivariate Logistic regression was used to an-alyze the influencing factors of depression.[Results]A total of 1879 valid questionnaires were collected in this study,and the detection rate of depression was 50.1%.The results of multivariate logistic analysis showed that compared with patients with middle school or below,the risk of depression was lower for those with postgraduate or above[OR=0.534,95%CI(0.341,0.835),P=0.006].Compared with antiviral therapy duration<1 year,antiviral therapy duration for 1 to 5 years[OR=0.729,95%CI(0.536,0.991)],>5 to 10 years[OR=0.516,95%CI(0.379,0.702)],>10 years[OR=0.603,95%CI(0.375,0.969)]was associated with a lower risk of depression.High level of social support was a protective factor for depression in HIV/AIDS patients compared with middle and low level of social support[OR=0.430,95%CI(0.349,0.530),P<0.001].There was a higher risk of depression with side effects than without side effects[OR=2.260,95%CI(1.833,2.786),P<0.001].The higher the score on the HIV stigma scale,the higher the possibility of depression was.[Conclusion]The detection rate of depression of patients receiving antiviral therapy in Nanjing is high.After starting antivi-ral therapy,we should strengthen the monitoring of side effects and psychological status of patients,carry out psychologi-cal intervention,alleviate psychological problems,and improve the quality of life of patients receiving antiviral therapy.
