Analysis of Depression and Influencing Factors in HIV/AIDS Patients Receiving Antiviral Therapy
10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.20240425.001
- VernacularTitle:抗病毒治疗HIV/AIDS患者抑郁状况及其影响因素分析
- Author:
Xin YUAN
1
;
Yuanyuan XU
2
;
Zhengping ZHU
2
;
Min ZHANG
2
;
Sushu WU
2
;
Jingwen WANG
2
;
Shaokang WANG
1
Author Information
1. Key Laboratory of Environmental Medicine and Engineering of Ministry of Education // Department of Nutrition and Food Hygiene， School of Public Health， Southeast University， Nanjing 210009， China
2. Department of AIDS and STD Control，Nanjing Municipal Center for Disease Control and Prevention，Nanjing 210003，China
- Publication Type:Journal Article
- Keywords:
antiviral therapy;
HIV/AIDS patients;
depression;
influencing factor;
logistic regression
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2024;45(3):438-445
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the depression status and its influencing factors in HIV/AIDS patients receiving antiviral therapy. MethodsFrom July 2022 to September 2022， successive sampling method was used to recruit HIV/AIDS patients receiving antiviral therapy from antiviral treatment institutions in Nanjing， and they were instructed to fill out anonymous questionnaires. The questionnaire collected the basic information of patients， and depression， HIV stigma score and social support level were investigated by Patient Health Questionnaire-9 （PHQ-9）， Berger HIV stigma scale （BHSS） and Multidimensional Scale of Perceived Social Support （MSPSS）. Multivariate Logistic regression was used to analyze the influencing factors of depression. ResultsA total of 1879 valid questionnaires were collected in this study， and the detection rate of depression was 50.1%. The results of multivariate logistic analysis showed that compared with patients with middle school or below， the risk of depression was lower for those with postgraduate or above ［OR=0.534， 95%CI （0.341， 0.835）， P=0.006］. Compared with antiviral therapy duration<1 year， antiviral therapy duration for 1 to 5 years ［OR=0.729， 95%CI （0.536， 0.991）］， >5 to 10 years ［OR=0.516， 95%CI （0.379， 0.702）］， >10 years ［OR=0.603， 95%CI （0.375， 0.969）］ was associated with a lower risk of depression. High level of social support was a protective factor for depression in HIV/AIDS patients compared with middle and low level of social support ［OR=0.430， 95% CI（0.349， 0.530）， P < 0.001］. There was a higher risk of depression with side effects than without side effects ［OR=2.260， 95%CI （1.833， 2.786）， P < 0.001］. The higher the score on the HIV stigma scale， the higher the possibility of depression was. ConclusionThe detection rate of depression of patients receiving antiviral therapy in Nanjing is high. After starting antiviral therapy， we should strengthen the monitoring of side effects and psychological status of patients， carry out psychological intervention， alleviate psychological problems， and improve the quality of life of patients receiving antiviral therapy.
