Research Progress on the Mechanisms of Berberine Protecting the Kidney in Diabetic Kidney Disease
10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.20240419.003
- VernacularTitle:小檗碱保护糖尿病肾病肾脏作用机制研究进展
- Author:
Bingheng QU
1
;
Xiaopeng TONG
1
Author Information
1. Xizang Minzu University， Xianyang 712082， China
- Publication Type:Review
- Keywords:
berberine （BBR）;
diabetic kidney disease （DKD）;
improved renal function;
mechanisms of action;
systematic review
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2024;45(3):354-360
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic kidney disease （DKD） is a chronic kidney disease caused by diabetes， influenced by genetic and environmental factors and their interaction. It is the primary cause of chronic kidney disease and end-stage renal disease. Recent studies have found， as a natural isoquinoline alkaloid， berberine （BBR） has hypoglycemic， hypolipidemic， antioxidant， anti-inflammatory and anti-fibrotic properties， thus protects against kidney injury in DKD. The mechanisms of action of BBR may involve improving glucolipid metabolism， reducing oxidative stress， alleviating inflammatory responses， mitigating renal fibrosis， regulating DNA methylation， promoting mitochondrial function and modulating the gut microbiota to enhance gut metabolism and clearance. This article systematically reviews the current status of research on the mechanisms of BBR in the treatment of DKD and provides reference for future clinical application of BBR in the treatment of DKD.
