The Role of TREM2 Receptor in Alzheimer's Disease

VernacularTitle:髓系细胞触发受体2在阿尔茨海默病中的作用
Author: Yuting DAI ¹ ; Jingming SHI
Author Information

1. 西藏民族大学医学院高原环境脑神经损伤与修复研究实验室,陕西咸阳,712082
Keywords: Alzheimer's disease; TREM2; microglia; β-amyloid; cell receptors
From: Journal of Sun Yat-sen University(Medical Sciences) 2024;45(3):344-353
CountryChina
Language:Chinese
Abstract: Alzheimer's disease(AD)is the most common form of senile dementia,and its pathogenesis is still un-clear.While β-amyloid(Aβ)is considered an important cause of AD,the pathological mechanism of Aβ inducing AD is subject to various controversies.Recent studies have shown that the myeloid cell trigger receptor(TREM2)plays an impor-tant role in the pathological process of AD,and it can not only serve as an important receptor for the internalization of Aβ but also become a biological diagnostic biomarker and therapeutic target.Hence,elucidating the structure and function of TREM2 will provide important ideas for the prevention and treatment of AD.This article will provide a systematic review of the structure of TREM2,its impact on microglial cell function,its pathological role in AD,and the current status of target-ed TREM2 therapy for AD.These summaries will provide valuable references for basic research on AD.