The Role of TREM2 Receptor in Alzheimer’s Disease

VernacularTitle:髓系细胞触发受体2在阿尔茨海默病中的作用
Author: Yuting DAI ¹ ; Jingming SHI ¹
Author Information

1. Brain Injury and Repair Research Laboratory in High Altitude Environment， School of Medicine， Xizang Minzu University， Xianyang 712082， China
Publication Type:Review
Keywords: Alzheimer's disease; TREM2; microglia; β-amyloid; cell receptors
From: Journal of Sun Yat-sen University(Medical Sciences) 2024;45(3):344-353
CountryChina
Language:Chinese
Abstract: Alzheimer's disease （AD） is the most common form of senile dementia， and its pathogenesis is still unclear. While β-amyloid （Aβ） is considered an important cause of AD， the pathological mechanism of Aβ inducing AD is subject to various controversies. Recent studies have shown that the myeloid cell trigger receptor （TREM2） plays an important role in the pathological process of AD， and it can not only serve as an important receptor for the internalization of Aβ but also become a biological diagnostic biomarker and therapeutic target. Hence， elucidating the structure and function of TREM2 will provide important ideas for the prevention and treatment of AD. This article will provide a systematic review of the structure of TREM2， its impact on microglial cell function， its pathological role in AD， and the current status of targeted TREM2 therapy for AD. These summaries will provide valuable references for basic research on AD.