Efficacy of Solifenacin in Children with Idiopathic Overactive Bladder
10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.20240424.003
- VernacularTitle:索利那新治疗儿童特发性膀胱过度活动症的疗效分析
- Author:
Ping HE
1
;
Ye ZHANG
1
;
Yin ZHANG
1
;
Qihang SUN
1
;
Long YOU
1
;
Min CHAO
1
Author Information
1. Anhui Provincial Children’s Hospital， Anhui Medical University， Hefei， Anhui 230051， China
- Publication Type:Journal Article
- Keywords:
overactive bladder （OAB）;
urinary incontinence;
urinary urgency;
children;
Solifenacin
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2024;45(3):337-343
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the efficacy of Solifenacin in the treatment of children with idiopathic overactive bladder （OAB）. MethodsThe study included 67 children with idiopathic OAB treated in the urology clinic of our hospital from March 2022 to March 2023. After at least 2-week-long behavioral therapy showed no significant therapeutic effect， 52 of the cases in the trial group were given oral Solifenacin 5 mg once daily and the other 15 cases in the control group continued the behavioral therapy. The cases in trial group were subdivided into OAB-dry group （27 cases without urinary incontinence） and OAB-wet group （25 cases with urinary incontinence）. The 3-day micturition diary， OAB Symptom Scores （OABSS） and the adverse reactions were recorded and analyzed before， at Weeks 2， 4， 8 and 12 after the treatment. ResultsOf all the 67 cases who completed a 3-month follow-up， 44 were cured including 41 in the trial group and 3 in the control group， 4 presented with adverse reactions. After the 3-month follow-up， the OABSS declined markedly in trial group than in control group （Z=4.524， P<0.001）； the cure rates in trial group and control group are 78.8% and 20% respectively， with significant difference （χ2=15.367， P<0.001）. At each follow-up，we found increased mean voided volume （F=9.707， P<0.001）， reduced mean voiding frequency during daytime （F=3.837， P=0.009） and decreased voiding urgency （χ2=482.835， P<0.001）. After the 3-month follow-up， the cure rates in OAB-dry group and OAB-wet group are 81.5% and 76% respectively， with no significant difference （χ2=0.234， P=0.629）. ConclusionsIn children with idiopathic OAB， oral Solifenacin 5 mg once daily could significantly increase mean voided volume， reduce mean voiding frequency during daytime， relieve symptoms of urinary urgency and lead to fewer adverse reactions， but is not significantly effective for the treatment of urinary incontinence in OAB-wet children .
