Effects of Modified Shenling Baizhu Powder （参苓白术散）and Xiaoluo Pills（消瘰丸）on Quality of Life and Serum Inflammatory Factors in Children with Adenoid Hypertrophy due to Spleen Deficiency and Phlegm Accumulation
10.13288/j.11-2166/r.2024.06.009
- VernacularTitle:参苓白术散合消瘰丸加减对脾虚痰聚型腺样体肥大患儿生活质量及血清炎症因子的影响
- Author:
Lixia ZHANG
1
;
Juan ZHANG
1
;
Huiping YI
1
Author Information
1. Xinyu Hospital of Traditional Chinese Medicine， Xinyu， 338000
- Publication Type:Journal Article
- Keywords:
adenoid hypertrophy;
spleen deficiency and phlegm accumulation;
Shenling Baizhu Powder （参苓白术散）;
Xiaoluo Pills （消瘰丸）;
inflammatory factors;
quality of life
- From:
Journal of Traditional Chinese Medicine
2024;65(6):594-599
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the clinical effect and possible mechanism of modified Shenling Baizhu Powder （参苓白术散） and Xiaoluo Pill （消瘰丸） in the treatment of children with adenoid hypertrophy due to spleen deficiency and phlegm accumulation. MethodsOne hundred and thirty children with adenoid hyperplasia due to spleen deficiency and phlegm accumulation were randomly divided into 65 cases each in the observation group and control group. The control group was given mometasone furoate nasal spray， one spray into each nostril， once a day， while the observation group was given modified Shenling Baizhu Powder and Xiaoluo Pill orally， one dose per day， and both groups were treated for 8 months. The pre- and after-treatment electronic nasopharyngoscope scores， specific quality of life survey scale （OSA-18） scores， total TCM symptom scores， serum cysteine leukotrienes （CysLTs）， interleukin 2 （IL-2）， tumor necrosis factor α （TNF-α）， and interleukin 10 （IL-10） levels were compared to determine the clinical efficacy after treatment. ResultsAfter treatment， the electronic nasopharyngoscope scores， OSA-18 scores， total TCM symptom scores， serum CysLTs， IL-2 and TNF-α levels significantly decreased， while IL-10 levels increased in both groups （P＜0.01）. Compared between the two groups after treatment， the electronic nasopharyngoscope score， OSA-18 score， total TCM symptom score， serum CysLTs， IL-2 and TNF-α levels were significantly lower， and the IL-10 level was higher in the observation group than in the control group （P＜0.01）. The total effective rate of the observation group was 95.38% （62/65）， superior to 81.54% （53/65） of the control group （P＜0.05）. ConclusionFor children with adenoid hypertrophy due to spleen deficiency and phlegm accumulation， modified Shenling Baizhu Powder and Xiaoluo Pill can help to improve symptoms， increase quality of life and clinical efficacy， and its mechanism may be related to reducing the inflammatory response.
