Clinical Characteristics and Use of Traditional Chinese Medicine Therapy in 222 Malignant Tumor Cases with COVID-19： A Retrospective Study
10.13288/j.11-2166/r.2024.07.010
- VernacularTitle:222例感染新型冠状病毒的恶性肿瘤患者临床特征及中医药应用情况回顾性研究
- Author:
Yingtian WANG
1
;
Hong SUN
1
;
Man LI
2
;
Na SONG
3
;
Jiao GOU
4
;
Wenfang LUO
5
;
Jun LIU
6
;
Rong MA
7
;
Wei WANG
1
;
Zhandong LI
1
;
Bo MENG
1
;
Xiaoyan YAO
8
Author Information
1. Beijing Cancer Hospital/Beijing Institute of Cancer Research， Beijing， 100142
2. Hubei Provincial Cancer Hospital
3. Chongqing Traditional Chinese Medicine Hospital
4. Shaanxi Traditional Chinese Medicine Hospital
5. The First Affiliated Hospital of University of South China
6. Nanjing Jiangbei Hospital Affiliated to Nantong University
7. Inner Mongolia Hospital of Traditional Chinese Medicine
8. Guang'anmen Hospital， China Academy of Chinese Medical Sciences
- Publication Type:Journal Article
- Keywords:
malignant tumors;
COVID-19;
traditional Chinese medicine therapy;
nucleic acid negative conversion time;
retrospective study
- From:
Journal of Traditional Chinese Medicine
2024;65(7):716-721
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo analyze the clinical characteristics and the use of traditional Chinese medicine （TCM） therapy in cancer patients with COVID-19， and to provide reference for making TCM prevention and treatment strategies and determining diagnosis and treatment priorities for patients with malignant tumors in the COVID-19 epidemic. MethodsThe medical records of 225 malignant tumor cases with COVID-19 who were admitted to 7 national research centers from January 1st to 20th， 2023 were retrospectively collected， and the main symptoms and duration after infection， nucleic acid negative conversion time， use of TCM therapy， and changes in adverse reactions after resuming anti-tumor treatment were analyzed. ResultsA total of 222 malignant tumor patients with COVID-19 were included in the analysis， involving 205 mild cases and 17 moderate cases. The top four most frequently reported clinical symptoms were fever （165 cases）， expectoration or dry cough （99 cases）， decreased appetite （95 cases） and fatigue （85 cases）， of which 40 expectoration or dry cough cases ， 37 fatigue cases and 29 decreased appetite cases lasted for more than 14 days. One hundred and five patients with nucleic acid detection report had a median negative conversion time of 14 days. The nucleic acid negative conversion time was significantly longer in patients with lung cancer compared to those with digestive system malignant tumors， and in those with myelosuppression than those without （P＜0.01）. During the infection period， 47.30% （105/222） of the patients used Chinese patent medicine， and 21.17% （47/222） were treated with herbal decoctions. The use of TCM in patients during the prevention and rehabilitation period， was 1.80%（4/222） and 7.21%（16/222）， respectively. Fifty-five patients resumed anti-tumor treatment after nucleic acid negative conversion， and received TCM simultaneously. Observed adverse reactions， including gastrointestinal reactions， bone marrow suppression， and neurotoxicity， were all grade 1 to 2， and no new adverse events occurred during follow-up. ConclusionCertain malignant tumor patients with COVID-19 had prolonged symptoms and nucleic acid negative conversion time Rational use of TCM can help to promote the rehabilitation of the patients and ensure the smooth process of anti-tumor treatment after infection.
