Discussion on the Targeting Mechanism of Qingre Huoxue Formula （清热活血方） for Treatment of Rheumatoid Arthritis by Regulating “Inflammation-Bone Destruction”：Based on LRG1/TGF- β Signalling Axis
10.13288/j.11-2166/r.2024.07.006
- VernacularTitle:基于LRG1/TGF⁃β信号轴探讨清热活血方调节“炎症-骨破坏”治疗类风湿关节炎的靶向作用机制
- Author:
Weixiang LIU
1
;
Yu SHI
2
;
Yanqiong ZHANG
3
;
Xun GONG
1
;
Quan JIANG
1
Author Information
1. Guang'anmen Hospital， China Academy of Chinese Medical Sciences， Beijing， 100053
2. Chaoyang Tenth Retired Cadre Rehabilitation Center of the Beijing Garrison of the People's Liberation Army of China
3. Institute Of Chinese Materia Medica， China Academy of Chinese Medical Sciences
- Publication Type:Journal Article
- Keywords:
rheumatoid arthritis;
damp-heat syndrome;
Qingre Huoxue Formula （清热活血方）;
inflammation;
bone destruction;
leucine rich α-2-glycoprotein 1;
transforming growth factor-β
- From:
Journal of Traditional Chinese Medicine
2024;65(7):691-696
- CountryChina
- Language:Chinese
-
Abstract:
Based on the previous publications， it is believed that damp-heat syndrome is the core syndrome of rheumatoid arthritis （RA）， and Qingre Huoxue Formula （清热活血方） is an effective formula for the treatment of damp-heat syndrome of RA. “Inflammation-bone destruction” is a key pathological link of RA， and it is also the advantage of the effectiveness of Qingre Huoxue Formula. Leucine rich α-2-glycoprotein 1 （LRG1） can mediate the transforming growth factor-β （TGF-β） signalling pathway to participate in the pathogenic process of “inflammation-bone destruction” of RA， and it can be used as a target protein in the treatment of damp-heat syndrome of RA by Qingre Huoxue Formula. Accordingly， a scientific hypothesis was proposed that Qingre Huoxue Formula may regulate TGF-β signalling pathway mediated by LRG1 to improve “inflammation-bone destruction” of RA， and it was envisioned that the clinical effect of Qingre Huoxue Formula on LRG1 could be confirmed through clinical studies， and the mechanism of action of Qingre Huoxue Formula on the LRG1/TGF-β signalling axis as well as the influence of the expression or non-expression of the LRG1/TGF-β signalling axis on the therapeutic effectiveness of Qingre Huoxue Formula could be clarified through animal experiments.
