Exploring the Ideas of Traditional Chinese Medicine in the Prevention and Treatment of Tumour Metastasis Exacerbated by Chronic Stress：from the Perspective of Abnormal Tumour Cell Adhesion
10.13288/j.11-2166/r.2024.09.005
- VernacularTitle:从肿瘤细胞黏附异常探讨慢性应激加剧肿瘤转移的中医药防治思路
- Author:
Fan ZHAO
1
;
Gang YIN
1
;
Feng TAN
1
;
Fang WEN
1
;
Rong QU
1
;
Decai TANG
1
Author Information
1. School of Traditional Chinese Medicine， Nanjing University of Chinese Medicine， Nanjing， 210023
- Publication Type:Journal Article
- Keywords:
tumour metastasis;
chronic stress;
tumor cell adhesion;
constraint and stagnation of the qi;
tumor toxin
- From:
Journal of Traditional Chinese Medicine
2024;65(9):898-903
- CountryChina
- Language:Chinese
-
Abstract:
Abnormal tumour cell adhesion is a key step in tumour metastasis， in which weakened homologous and enhanced heterologous adhesion of tumour cells is an important cause of tumour metastasis. Chronic stress can activate the sympathetic nervous system to link and regulate the homologous and heterologous adhesion of tumour cells and exacerbate tumour metastasis. Combining the understanding of traditional Chinese medicine （TCM） and Western medicine on tumour metastasis， it is believed that the mechanism of "qi constraint and stagnation， tumor toxin transmission and retention" in TCM theory is highly related to the abnormal adhesion of tumour cells triggered by chronic stress. Qi constraint and stagnation is closely related to chronic stress and its activation of the sympathetic nervous system， and transmission and retention of tumor toxin explained the mechanism of tumour metastasis due to abnormal adhesion of tumour cells from the perspective of TCM. By regulating the key link of sympathetic nervous system-tumour cell adhesion， application of the formulas of regulating qi and resolving toxin can improve chronic stress and inhibit tumour metastasis.
