Construction of Meridian and Collateral Homeostasis Model from Phenomics
10.13288/j.11-2166/r.2024.10.002
- VernacularTitle:从表型组学探讨经络稳态动态映射模型
- Author:
Jiaqi SUN
1
;
Luxia JIANG
1
;
Zheng YU
1
;
Zhenmei DU
1
;
Shengyan ZHANG
1
;
Yusheng TANG
1
;
Ziqian WANG
1
;
Xianfeng CAO
1
;
Chuanbiao WEN
1
Author Information
1. Chengdu University of Traditional Chinese Medicine， Chengdu， 611137
- Publication Type:Journal Article
- Keywords:
meridians and collaterals;
homeostasis;
phenomics;
concept of holism
- From:Journal of Traditional Chinese Medicine
2024;65(10):990-995
- CountryChina
- Language:Chinese
-
Abstract:
By applying "homeostasis" to the study of the meridian and collateral system， the concept of meridian and collateral homeostasis has been proposed which refers to a balanced and stable state of meridian and collateral system， and plays an important role in maintaining body health and can provide a reference for the diagnosis and treatment of diseases. Phenomics realizes the cross-scale correlation from micro-phenotypic data， such as genome， proteome， and metabolome， to macro-phenotypic data， such as physiological state， behavioral activities， and external manifestations. From the perspective of phenomics， this paper proposes a meridian and collateral homeostasis dynamic mapping model of "macroscopic signs and microscopic expression". This model combines macro signs such as the four examinations of traditional Chinese medicine （TCM）， biophysical indicators of acupoints， and micro expression information such as genes， proteins， and metabolism， and systematically investigates the relationship between meridian and collateral homeostasis and health and disease， thereby providing ideas and references for the identification of pre-disease states as well as precise diagnosis and treatment in TCM.
