A case of pemphigus foliaceus in a 40-year-old female successfully treated with doxycycline and prednisone combination therapy
- Author:
Jobelline Mae C. Fernandez
1
;
Mae Ramirez-Quizon
2
Author Information
- Publication Type:Journal Article
- MeSH: Pemphigus; Clobetasol; Enzyme-Linked Immunosorbent Assay
- From: Journal of the Philippine Medical Association 2024;102(2):77-80
- CountryPhilippines
- Language:English
- Abstract: Here, we present a 40-year-old female with multiple pruritic occasionally painful vesicles, papules, and plaques in a circinate pattern on seborrheic areas, progressing to erosions and scales. Clinical findings led to the diagnosis of pemphigus foliaceus (PF). Initial treatment with prednisone and clobetasol ointment, however, did not fully suppress blister formation and healing of erosions. Skin punch biopsy revealed a subcorneal split and intracorneal neutrophilic infiltrates, while enzymelinked immunoassay (ELISA) revealed elevated anti-desmoglein 1 (Dsgl), consistent with PF. Doxycycline was then added to the previous regimen, resulting in remission. We discuss the role of doxycycline as a cost-effective adjunctive treatment in patients with refractory PF.
- Full text:2024060416003359249A Case of Pemphigus Foliaceus.pdf
