Influencing factors of follow-up compliance of special diet therapy in patients with phenylketonuria in four prefectures of Xinjiang Uygur Autonomous Region
10.11852/zgetbjzz2023-0336
- VernacularTitle:新疆地区四地州苯丙酮尿症患者特食治疗随访依从性的影响因素
- Author:
Shangqin ZHOU
1
,
2
;
Xi CHEN
3
;
Shuyuan XUE
4
;
Luhan ZHANG
5
;
Guifeng DING
6
Author Information
1. School of Nursing, Hexi University, Zhangye, Gansu 734000, China
2. School of Public Health, Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region 830000, China
3. Department of Child Rehabilitation, Urumqi Maternal and Child Health Care Hospital
4. Urumqi Maternal and Child Health Care Hospital Neonatal Disease Screening Center
5. Department of Science and Education, Urumqi Maternal and Child Health Care Hospital
6. Department of Obstetrics, Urumqi Maternal and Child Health Hospital
- Publication Type:Journal Article
- Keywords:
phenylketonuria;
phenylalanine;
special diet treatment;
compliance
- From:
Chinese Journal of Child Health Care
2024;32(2):191-195
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To investigate the influencing factors behind the follow-up compliance of patients with low/no phenylketonuria (PKU) for special medical use, in order to provide a basis for regulating the follow-up of PKU patients and ensuring the effectiveness of special diet treatment. 【Methods】 A survey was conducted on PKU patients treated in Urumqi Maternal and Child Health Hospital for over 1 year, from January 2010 to December 2020. Interviews and questionnaires were conducted with their caregivers to collect and analyze the current status of PKU patients undergoing special diet treatment, and to identify the influencing factors behind their compliance with follow-up treatment. 【Results】 Patients who had received neonatal disease screening, neonatal gene diagnosis, and maternal Down′s screening during pregnancy had better compliance, with statistically significant differences (χ2=5.753, 10.993, 9.189, P<0.05). PKU children with parents who had a college education or above showed significantly higher adherence to special diet treatment (χ2=8.321, 7.415, P<0.05). PKU children with parents having a fixed occupation also showed higher compliance, with a statistically significant difference (χ2=20.626, 7.895, P<0.05). Patient age, interval of buying special diet, number of blood samples sent and enrollment of normal age, all had a significant impact on the follow-up compliance of PKU patients with special diet (χ2=19.443, 8.090, 69.482, 12.001, P<0.05). 【Conclusions】 PKU is a treatable genetic metabolic disease. Strengthening health education, formulating standardized follow-up plans and procedures, and improving follow-up treatment compliance are crucial in enhancing the treatment and follow-up effectiveness of PKU patients.
