Study on the diagnostic utility of serum levels of insulin-like growth Factor-I and insulin-like growth factor binding protein-3 in growth hormone deficiency.
10.3345/kjp.2008.51.12.1329
- Author:
Geun Ha CHI
1
;
Jeong Nyeo LEE
;
Woo Yeong CHUNG
Author Information
1. Department of Pediatrics, College of Medicine, Inje University, Busan, Korea. chungwy@chollian.net
- Publication Type:Original Article
- Keywords:
Insulin-like growth factor-I;
Insulin-like growth factor binding protein-3;
Growth hormone deficiency
- MeSH:
Aged;
Carrier Proteins;
Child;
Growth Hormone;
Humans;
Immunoradiometric Assay;
Insulin-Like Growth Factor Binding Protein 3;
Insulin-Like Growth Factor I;
Radioimmunoassay;
ROC Curve;
Sensitivity and Specificity
- From:Korean Journal of Pediatrics
2008;51(12):1329-1335
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: This study aimed to determine the best cutoff line for insulin-like growth factor (IGF)-I and insulin-like growth factor binding protein (IGFBP)-3 to discriminate between growth hormone deficiency (GHD) patients and the control group. METHODS: Two hundred thirty subjects with normal controls (129 boys and 101 girls, aged 7-15 years), 14 patients with complete GHD (12 boys and 2 girls), and 17 patients with partial GHD (9 boys and 8 girls) were studied. IGF-I serum concentrations were measured by radioimmunoassay (RI), and IGFBP-3 concentrations were measured by immunoradiometric assay (IRMA). RESULTS: The receiver operating characteristic (ROC) plot analysis showed that the best IGF-I and IGFBP-3 cutoff line was at -1 standard deviation (SD). By comparing IGF-I serum levels of GHD children within 1 SD of normal control, we determined the sensitivity (S) (87.5-100%) and specificity (Sp) (80-84.6%) according to the age group. For IGFBP-3 , we determined the following values: S (58.7-85.7%) and Sp (79.2-85.5%). Eleven of 1 4 patients with complete GHD (78.5%) and 16 of 17 patients with partial GHD (94.1%) had IGF-I concentrations equal to or below -1 SD of the control group mean. Ten of 12 complete GHD children (83.3%) and 13 of 17 partial GHD children (76.5%) had IGFBP-3 concentrations equal or below -1 SD of the control group mean. CONCLUSION: We conclude that the measurement of IGF-I and IGFBP-3 concentrations might provide essential supplementary data in the diagnostic evaluation of patients with GHD. Our results support the need to use cutoff lines based on below -1 SD of the control.
