Research progress in the relationship between vitamin D deficiency and central precocious puberty in children
10.11852/zgetbjzz2023-0209
- VernacularTitle:维生素D缺乏与儿童中枢性性早熟关系研究进展
- Author:
Xiaoqi LIU
1
,
2
;
Kundi WANG
3
;
Jun WANG
3
;
Zecheng LI
4
Author Information
1. Beijng University of Chinese Medicine, Beijing 100029, China
2. Department of Pediatrics, China-Japan Friendship Hospital, Beijing 100029, China
3. Department of Pediatrics, China-Japan Friendship Hospital, Beijing 100029, China
4. China-Japan Friendship Institute of Clinical Medicine
- Publication Type:Journal Article
- Keywords:
vitamin D;
central precocious puberty;
child
- From:
Chinese Journal of Child Health Care
2024;32(1):59-63
- CountryChina
- Language:Chinese
-
Abstract:
Central precocious puberty (CPP) is an endocrine disease of children due to the early onset of hypothalamic-pituitary-gonadal axis function. This leads to increased secretion of gonadotropin release impulse, causing the development of internal and external genitalia and the presentation of secondary sex characteristics. Studies have found that the onset of CPP in children may be related to vitamin D deficiency. Vitamin D, affected by sunlight duration, acts on neurons and neurotransmitters in the hypothalamic-pituitary-gonadal axis, promotes obesity and affects the expression level of insulin-like growth factor-1, which are four factors involved in the occurrence and development of CPP. The overall effect of vitamin D combined with gonadotropin-releasing hormone analogues on CPP is significant. This article reviews the correlation between vitamin D deficiency and CPP, as well as the possible mechanism of action, in order to provide some theoretical basis for researchers.
