Isoimperatorin alleviates acetic acid-induced colitis in rats

Saied Goodarzi; Amir Hossein Abdolghaffari; Behnaz Najafi; Mostafa Pirali Hamedani; Saeed Tavakoli; Mahshad Marvi; Maryam Baeeri; Narguess Yassa; Abbas Hadjiakhoondi; Mohammad Abdollahi; Zahra Tofighi

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Isoimperatorin alleviates acetic acid-induced colitis in rats

Author: Saied Goodarzi ¹ ; Amir Hossein Abdolghaffari ² ; Behnaz Najafi ³ ; Mostafa Pirali Hamedani ³ ; Saeed Tavakoli ⁴ ; Mahshad Marvi ⁵ ; Maryam Baeeri ⁶ ; Narguess Yassa ³ ; Abbas Hadjiakhoondi ^{1
,

7} ; Mohammad Abdollahi ^{3
,

8} ; Zahra Tofighi ^{1
,

7}
Author Information

1. Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
3. Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
4. Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
5. International Campus School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
6. Toxicology and Diseases group, The Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
7. Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
8. Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
Publication Type:Journal Article
Keywords: Isoimperatorin; Inflammatory bowel disease; Acetic acid; Colitis; TNF-α; IL-1β
From:Asian Pacific Journal of Tropical Biomedicine 2024;14(4):147-153
CountryChina
Language:English
Abstract: Objective: To investigate the effect of isoimperatorin on histopathological and biochemical changes in acetic acid-induced colitis rats. Methods: Colitis was induced by intracolonic administration of acetic acid solution (4% v/v) in rats. Rats were divided into six groups including the sham group, the negative control group, the dexamethasone-treated group, and the groups treated with isoimperatorin (0.1, 1, and 10 mg/kg/d by gavage). The treatments were administered for three days and then colonic status was assessed by macroscopic, histopathological, and biochemical analyses. Results: Isoimperatorin significantly alleviated colonic damage in a dose-dependent manner and improved histological changes in rats with acetic acid-induced colitis. It also significantly reduced myeloperoxidase, TNF-α, IL-1β, and malodialdehyde levels. Conclusions: Isoimperatorin alleviates acetic acid-induced colitis in rats and may be a potential therapeutic agent for the treatment of colitis.
Full text:20240402.pdf