Mechanism and Research Progress of Banxia Xiexintang in Treating Ulcerative Colitis Based on Shanghanlun
10.13422/j.cnki.syfjx.20241490
- VernacularTitle:基于《伤寒论》探讨半夏泻心汤类方治疗溃疡性结肠炎的机制及研究进展
- Author:
Yafen ZHANG
1
;
Zhenkui ZUO
2
;
Tianrui LIU
1
Author Information
1. Henan University of Chinese Medicine，Zhengzhou 450046，China
2. Henan Province Hospital of TCM/The Second Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450002，China
- Publication Type:Journal Article
- Keywords:
Shanghanlun;
Banxia Xiexintang;
ulcerative colitis;
research progress;
mechanism
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(13):279-288
- CountryChina
- Language:Chinese
-
Abstract:
The persistent，difficult-to-treat，and recurrent abdominal pain，diarrhea，and mucinous bloody stools that characterize ulcerative colitis （UC） are indicative of an inflammatory bowel disorder. The cause of the sickness remains uncertain，and the outcome of modern medical treatment is not encouraging. The incidence of UC has been steadily increasing over time，making it essential to discover novel treatments in clinical practice. For centuries，traditional Chinese medicine （TCM） has been a successful method for preventing and curing this malady. In the original text of Shanghanlun， ZHANG Zhongjing repeatedly discussed symptoms similar to UC，such as diarrhea，chronic dysentery，intestinal wind，and visceral toxins. The effective formulas proposed in Shanghanlun have laid the groundwork for the later use of TCM for treatment of UC. Research in recent times has revealed the distinct benefits of TCM in both relieving the symptoms and improving the quality of life of UC patients. Banxia Xiexintang，a compound of this type，has been found to be effective in network pharmacology，molecular docking，clinical observation，and animal experiments，and its therapeutic effects have been considerable in the treatment of UC. Extensive experiments have revealed a strong correlation between the effectiveness of Banxia Xiexintang in treating UC and factors such as inflammatory cytokines，intestinal microbiota，immune responses，related signaling pathways， and pyroptosis. This article presents a comprehensive examination of Banxia Xiexintang for treatment of UC，encompassing its theoretical basis，drug composition，and mechanism of action. This paper is expected to provide more theoretical support for clinical application of Banxia Xiexintang.
