Anticancer Mechanism of Hesperidin and Its Derivatives： A Review
10.13422/j.cnki.syfjx.20240217
- VernacularTitle:橙皮苷及其衍生物抗癌作用机制的研究进展
- Author:
Xiurong TIAN
1
;
Hao WANG
1
;
Penglong YU
2
;
Shimeng LYU
1
;
Yonghua LI
2
;
Xianglin JIANG
2
;
Qin YANG
2
;
Wubin LYU
3
;
Xia LIU
2
;
Yuexiang MA
1
Author Information
1. Shandong University of Traditional Chinese Medicine， Jinan 250355， China
2. Chongqing Three Gorges Medical College， Chongqing 404120， China
3. The People's Hospital Affiliated to Chongqing Three Gorges Medical College， Chongqing 404120， China
- Publication Type:Journal Article
- Keywords:
hesperidin;
derivatives;
anti-cancer;
mechanism of action;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(13):259-270
- CountryChina
- Language:Chinese
-
Abstract:
This article reviews relevant literature on the prevention and treatment of cancer with hesperidin published in the past 10 years by searching electronic databases such as China National Knowledge Infrastructure（CNKI）， Wanfang， and PubMed， and summarizes the research progress on the anticancer mechanism of hesperidin. Hesperidin has a wide range of pharmacological effects， including anti-inflammatory， antioxidant， antibacterial， antiviral， anticancer， immune-regulatory， anti-radiation， neuroprotective and cardiovascular protective properties and so on. Its anticancer mechanisms mainly include inhibiting cancer cell proliferation， promoting apoptosis， reducing angiogenesis， inhibiting invasion and migration of cancer cells， regulating immunity and autophagy， and exerting antioxidant and anti-inflammatory effects. As a broad-spectrum anticancer drug， hesperidin manifests chemo-preventive and therapeutic effects across various cancers， contingent upon its multifaceted anticancer mechanisms. Furthermore， this article summarizes the synergistic effects of hesperidin in combination with cisplatin， doxorubicin， cyclophosphamide and paclitaxel. It elucidates that hesperidin can enhance the cytotoxicity of these anticancer drugs against cancer cells while mitigating drug resistance and adverse side effects. Nonetheless， the clinical use is somewhat constrained due to its poor water solubility and limited bioavailability. Therefore， this article also outlines the current strategies for enhancing hesperidin's bioavailability， including structural modification， combination with other chemical substances， and utilization of nano drug carriers.The discovery of derivatives of hesperidin not only preserves the anticancer efficacy of hesperidin, but also effectively overcomes the shortcomings of poor water solubility and low bioavailability of hesperidin, effectively predicting the good application prospects of hesperidin and its derivatives.
