Effect of Tongdu Huoxue Decoction on Lumbar Spine Function and Serum Inflammatory Factor Levels in Patients with Acute Lumbar Disc Herniation
10.13422/j.cnki.syfjx.20241493
- VernacularTitle:通督活血汤对腰椎间盘突出症急性期患者腰椎功能及血清炎症因子水平的影响
- Author:
Yumo XIONG
1
;
Zichen LI
1
;
Ying LI
2
;
Qiangbing XIAO
2
;
Lihua WANG
3
;
Hao HU
1
;
Ruibing FENG
1
;
Jie QIAO
1
;
Yan HU
4
Author Information
1. Bone Injury Diagnosis and Treatment Center of Hubei Research Institute of Traditional Chinese Medicine，Hubei Provincial Hospital of Traditional Chinese Medicine（TCM）/Affiliated Hospital of Hubei University of Chinese Medicine，Wuhan 430074，China
2. School of Acupuncture and Moxibustion and Orthopaedics， Hubei University of Chinese Medicine，Wuhan 430074，China
3. Department of TCM，Jianghan University，Wuhan 430074，China
4. Honghu City Hospital of TCM/Honghu Hospital of TCM Affiliated to Hubei University of Chinese Medicine，Jingzhou 433200，China
- Publication Type:Journal Article
- Keywords:
disc herniation;
traditional Chinese medicine therapy;
lumbar spine function;
inflammatory factors
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(13):135-141
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo observe the clinical efficacy of Tongdu Huoxue decoction in the treatment of acute lumbar disc herniation （LDH）. MethodA total of 316 patients with acute LDH admitted to the orthopedic outpatient department of Hubei Provincial Hospital of Traditional Chinese Medicine and Honghu City Hospital of Traditional Chinese Medicine from January 2020 to June 2023 were randomly divided into two groups. 156 cases in the control group （two cases with stopped follow-up） were treated with meloxicam tablets， while 153 cases in the observation group （five cases with stopped follow-up） were treated with Tongdu Huoxue decoction. Both groups were treated for three months. The clinical efficacy， McGill Pain Score Scale （SF-MPQ）， Oswestry Dysfunction Index （ODI） score， and the Japanese Orthopaedic Association （JOA） scores of the two groups before and after treatment were compared. The serum levels of interleukin-1β （IL-1β）， interleukin-6 （IL-6）， and tumor necrosis factor-α （TNF-α） of the patients before and after treatment were determined by using enzyme-linked immunosorbent assay （ELISA）. The NDI-092 type electromyography-evoked potential instrument was adopted to measure the motor conduction velocity and clinical efficacy of the tibial and common peroneal nerves in patients of the two groups before and after treatment， and the clinical safety of the two groups of patients was compared. ResultAfter treatment， the total effective rate in the observation group was 95.4% （146/153）， significantly higher than that in the control group of 76.3% （119/156） （χ2 =23.18， P<0.05）. After treatment， both groups showed significant reductions in SF-MPQ and ODI scores， as well as the levels of IL-1β， IL-6， and TNF-α （P<0.05）， with the observation group showing a more significant reduction （P<0.05）. Both groups showed a significant increase in JOA scores and motor conduction velocities of the tibial and common peroneal nerves after treatment （P<0.05）， with the observation group showing a more significant increase （P<0.05）. ConclusionTongdu Huoxue decoction can alleviate lumbar and leg pain in acute LDH， improve lumbar spine function， and suppress inflammatory reactions. It is highly safe and is worthy of clinical promotion.
