Analysis of factors influencing the complication of dry eye after corneal transplantation and construction of nomogram predictive model
10.3980/j.issn.1672-5123.2024.6.25
- VernacularTitle:角膜移植术后并发干眼的影响因素分析及列线图预测模型构建
- Author:
Hongliang XU
1
;
Qian KANG
1
;
Zhiying MA
1
Author Information
1. Chengdu Aidi Eye Hospital,Chengdu 610031, Sichuan Province, China
- Publication Type:Journal Article
- Keywords:
corneal transplantation;
dry eye;
influencing factors;
nomogram;
predictive model construction
- From:
International Eye Science
2024;24(6):970-974
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To analyze the influencing factors of postoperative dry eye complication after corneal transplantation and to build a nomogram prediction model.METHODS: Clinical data were collected on 117 patients who underwent corneal transplantation at our hospital from March 2021 to February 2023. They were divided into dry eye group(n=96)and non-dry eye group(n=21)according to whether there was a postoperative dry eye. The risk factors of postoperative complication of dry eye after corneal transplantation were analyzed, the nomogram prediction model for predicting postoperative complication of dry eye after corneal transplantation was constructed, and the internal validation of the model and the prediction efficacy were assessed by calibration curves and decision curves, respectively.RESULTS: Comorbid diabetes mellitus, comorbid sleep disorders, comorbid meibomian gland dysfunction, chronic eye drop abuse, chronic corneal contact lens wear, interleukin-6(IL-6), and tumor necrosis factor-α(TNF-α)were the risk factors for the complication of dry eye after corneal transplantation(P<0.05). The nomogram model predicted a C-index of 0.890(95% CI 0.877-0.903). The nomogram model had a threshold >0.07, and the nomogram model provided higher net clinical benefit than the single index in all cases.CONCLUSION: The nomogram model built in this study based on the factors affecting the complication of dry eye after corneal transplantation has a good predictive value for the complication of dry eye after corneal transplantation.
