Efficacy comparison of botulinum toxin A injection and extraocular muscle surgery in the treatment of large angle acute acquired concomitant esotropia

Jiong Zhang; Lijuan Lang; Junbo Rong; Limin XU; Kexin Guo; Luxi Zhang; Ying Wang; Yujie Liu; Zhigang LI

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Efficacy comparison of botulinum toxin A injection and extraocular muscle surgery in the treatment of large angle acute acquired concomitant esotropia

VernacularTitle:A型肉毒毒素与眼外肌手术治疗大角度急性共同性内斜视的疗效对比
Author: Jiong ZHANG ^{1
,

2} ; Lijuan LANG ^{1
,

2} ; Junbo RONG ^{1
,

2} ; Limin XU ^{1
,

2} ; Kexin GUO ^{1
,

2} ; Luxi ZHANG ^{1
,

2} ; Ying WANG ^{1
,

2} ; Yujie LIU ^{1
,

2} ; Zhigang LI ^{1
,

2}
Author Information

1. Department of Ophthalmology, the First Affiliated Hospital of Zhengzhou University
2. Henan Provincial Ophthalmic Hospital, Zhengzhou 450000, Henan Province, China
Publication Type:Journal Article
Keywords: acute disease; esotropia; botulinum toxin A; extraocular muscle surgery; injection dosage; efficacy
From: International Eye Science 2024;24(6):960-964
CountryChina
Language:Chinese
Abstract: AIM: To explore the variance in efficacy between botulinum toxin A(BTA)injection and extraocular muscle surgery in managing large-angle(≥+60 PD)acute acquired concomitant esotropia(AACE).METHODS: A retrospective analysis was conducted on clinical data of 60 patients with AACE treated at our hospital from June 2020 to December 2022. Patients were divided into three groups based on different treatments: 2.5 IU BTA injection group(14 cases), 5.0 IU BTA injection group(29 cases), and surgical group(17 cases). Follow-up was conducted for 6 mo after treatment to observe the degree of strabismus after the correction of refractive error, visual function, treatment effectiveness, and occurrence of complications after BTA injection.RESULTS: At 6 mo post-treatment, the degree of strabismus in the surgical group and the 5.0 IU BTA injection group was lower than that in the 2.5 IU BTA injection group(P<0.017). However, there was no significant difference in the degree of strabismus between the surgical group and the 5.0 IU BTA injection group(P>0.017). The effective rate of the 5.0 IU BTA injection group was higher than that of the 2.5 IU BTA injection group(86% vs 43%, P<0.017). There was no difference in visual function among the three groups(P>0.05). The incidence of complications after treatment was not significantly different between the 2.5 IU BTA injection group and the 5.0 IU BTA injection group(43% vs 52%, P>0.05).CONCLUSION: For AACE patients with esotropia degree ≥+60 PD, bilateral medial rectus injection of 5.0 IU BTA can yield outcomes comparable to traditional extraocular muscle surgery, with the advantages of minimal trauma and simple and convenient operation.