Research progress on the role of NLRP3 inflammasome signaling pathway in the occurrence and development of retinal diseases
10.3980/j.issn.1672-5123.2024.6.12
- VernacularTitle:NLRP3炎症小体信号通路在视网膜疾病发生发展中的作用
- Author:
Xiaohui LI
1
,
2
;
Lianji TIAN
1
,
2
;
Jingyun SHI
1
,
2
;
Xin AN
1
,
2
;
Chunyu WANG
1
,
2
;
Renzhe CUI
1
,
2
;
Jun CUI
1
,
2
Author Information
1. Department of Ophthalmology, Yanbian University Hospital, Yanji 133000, Jilin Province, China
2. Yanbian University, Yanji 133000, Jilin Province, China
- Publication Type:Journal Article
- Keywords:
Nod-like receptor protein 3(NLRP3)inflammasome;
diabetic retinopathy;
retinal ischemia-reperfusion;
proliferative vitreoretinopathy
- From:
International Eye Science
2024;24(6):902-905
- CountryChina
- Language:Chinese
-
Abstract:
The nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3)inflammasome is an inflammatory protein complex, and can participate into the inflammatory response. Upon activation, these inflammasomes can lead to Caspase-1 activation, thereby inducing a cascade of inflammatory factor activation and further cell pyroptosis. Excessive activation of inflammasomes will induce the overexpression of inflammatory factors, persistently triggering immune dysregulation and inflammatory chain reactions, even causing severe damage. The recent studies have confirmed a close association between retinal diseases, such as diabetic retinopathy(DR), retinal ischemia-reperfusion injury(RIRI), and proliferative vitreoretinopathy(PVR)with immune dysregulation and inflammatory responses, which is serving as crucial factors in the progression of retinal diseases. This article reviews the NLRP3 inflammasome signaling pathway and its role in the occurrence and development of retinal diseases, in order to provide new ideas for the pathogenesis and prevention of retinal diseases.
