Role of β-glucuronidase in the formation of primary intrahepatic stones
- VernacularTitle:β-葡萄糖醛酸酶(GUS)在原发性肝内胆管结石形成中的作用
- Author:
Guo LI
1
;
Haijun YE
;
Zhikai XU
;
Wentao LI
;
Chenglei XU
;
Jiang LI
Author Information
- Keywords: Gallstones; Glucuronidase; Pathologic Processes
- From: Journal of Clinical Hepatology 2024;40(5):1057-1061
- CountryChina
- Language:Chinese
- Abstract: Primary intrahepatic stones(PIS)is a refractory disease with a high incidence rate in Southwest China,which greatly affects the life of patients.Metabolites,such as β-glucuronidase produced by chronic biliary tract infection,play an important role in the formation of pigmented stones.In addition to exogenous β-glucuronidase produced by bacteria,endogenous β-glucuronidase produced by intrahepatic bile duct cells also plays an important role in the formation of stones.This article analyzes the research advances in the role of β-glucuronidase in the pathogenesis of PIS,in order to provide a possible method for the prevention and treatment of PIS.
