The relationship between the Wnt signaling pathway and liver regeneration and its role in liver diseases

VernacularTitle:Wnt信号通路与肝再生的关系及其在肝脏疾病中的作用
Author: Yupei LIN ¹ ; Xiaoping LIU ¹ ; Yinbing LUO ¹ ; Feiyan LI ¹ ; Yingying LIAO ¹ ; Shicong MO ¹ ; Dewen MAO ¹ ; Yanmei LAN ²
Author Information

1. Key Laboratory of Traditional Chinese Medicine Clinical Research
2. Guangxi Key Laboratory of Molecular Biology in Traditional Chinese Medicine Prevention and Treatment， The First Affiliated Hospital of Guangxi University of Chinese Medicine， Nanning 530023， China
Publication Type:Review
Keywords: Liver Diseases; Liver Regeneration; Wnt Signaling Pathway; beta Catenin
From: Journal of Clinical Hepatology 2024;40(5):1050-1056
CountryChina
Language:Chinese
Abstract: The Wnt signaling pathway plays an important role in maintaining liver homeostasis and liver regeneration. In healthy livers， the Wnt signaling pathway is mostly inactive， but it is continuously overactivated during cell renewal or regeneration processes， as well as in certain pathological conditions， diseases， precancerous states， and cancers. Persistent liver cell injury often leads to chronic liver diseases such as liver fibrosis， liver cirrhosis， and liver cancer. This article summarizes the basic structural features of the Wnt signaling pathway and analyzes its important role in the pathological progression of various liver diseases， so as to provide new ideas for the prevention and treatment of liver diseases in clinical practice.