Research advances in liver macrophages regulating malignant transformation of hepatic precancerous lesions

Ruijuan Yan; Junzhe Jiao; Yu Huang; Shuguang Yan; Hailiang Wei; Zhanjie Chang; Yingjun Guo; Jingtao LI

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Research advances in liver macrophages regulating malignant transformation of hepatic precancerous lesions

VernacularTitle:肝巨噬细胞调控肝癌癌前病变恶变的研究进展
Author: Ruijuan YAN ¹ ; Junzhe JIAO ¹ ; Yu HUANG ² ; Shuguang YAN ² ; Hailiang WEI ¹ ; Zhanjie CHANG ¹ ; Yingjun GUO ³ ; Jingtao LI ¹
Author Information

1. Liver Disease Hospital Ward One， The Affiliated Hospital of Shaanxi University of Chinese Medicine， Xianyang， Shaanxi 712000， China
2. First Clinical Medical College， Shaanxi University of Chinese Medicine， Xianyang， Shaanxi 712000， China
3. Department of Infectious Diseases， People’s Hospital of Ningxia Hui Autonomous Region， Yinchuan 750002， China
Publication Type:Review
Keywords: Carcinoma， Hepatocellular; Liver Macrophage; Hepatic Progenitor Cell Malignant Transformation
From: Journal of Clinical Hepatology 2024;40(5):1039-1043
CountryChina
Language:Chinese
Abstract: Liver macrophages are important immune cells in the liver， and they express proinflammatory factors and anti-inflammatory factors through polarization into M1 type and M2 type， respectively， thereby playing a role in regulating inflammatory damage response. The malignant transformation of hepatic progenitor cells is the core mechanism of the malignant progression of hepatic precancerous lesions， and its key factor is the continuous stimulation of inflammatory microenvironment， which is closely associated with M1/M2 macrophage polarization. This review mainly focuses on the association between macrophage polarization， chronic inflammation， and malignant transformation of hepatic progenitor cells， so as to provide a theoretical basis for the prevention and treatment of hepatic precancerous lesions.