Histological Characteristics of the Kidney in Mongolian Gerbils of Different Ages
10.12300/j.issn.1674-5817.2022.130
- VernacularTitle:不同月龄长爪沙鼠的肾脏组织学特征
- Author:
Lingqun LU
1
;
Honggang GUO
1
;
Qiaojuan SHI
1
;
Fangwei DAI
1
;
Xiaofeng CHU
1
Author Information
1. Experimental Animal Center of Hangzhou Medical College, Zhejiang Provincial Key Laboratory of Laboratory Animal and Safety Research, Hangzhou 310000, China
- Publication Type:Journal Article
- Keywords:
Mongolian gerbil;
Kidney;
Histological change
- From:
Laboratory Animal and Comparative Medicine
2023;43(1):61-66
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the histological characteristics of the kidney in Mongolian gerbils of different ages. MethodsTen Mongolian gerbils of 2, 6, and 12 months old (half male and half female) were selected. After euthanasia, the kidneys were taken and paraffin sections were made. After HE, MASSON and PAS staining, the structural differences of different parts of the kidney tissue in gerbils of different ages were observed by digital scanning, and the relevant data of the kidney tissue were measured by image analysis software. ResultsThe number of proximal convoluted tubules was more than that of distal convoluted tubules in the renal cortex and outer medulla of gerbils. With age, the glomerular density decreased, the glomerular diameter increased, the basement membrane of renal tubules thickened, and the fibrous components between renal tubules increased. ConclusionThe histological structure of Mongolian gerbil's kidney varies with age, which may be related to glomerulosclerosis and parenchymal cell reduction. The specific mechanism needs further study.
