Explanation and Elaboration for the ARRIVE Guidelines 2.0—Reporting Animal Research and In Vivo Experiments (Ⅰ)
10.12300/j.issn.1674-5817.2023.043
- VernacularTitle:《动物研究：体内实验报告》即ARRIVE 2.0指南的解释和阐述（一）
- Author:
Jian WANG
1
;
Jin LU
1
;
Zhengwen MA
1
;
Guoyuan CHEN
2
;
Xiao LU
3
;
Yu BAI
4
;
Xiaoyu LIU
5
;
Xuancheng LU
6
;
Jing GAO
7
;
Yao LI
1
;
Wanyong PANG
8
Author Information
1. Department of Laboratory Animal Science, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China
2. Animal Core Facility, Center for Excellence in Molecular Cell Science, Chinese Academy of Science, Shanghai 200031, China
3. Dizal Pharmaceuticals Co., Ltd., Shanghai 201203, China
4. Novo Nordisk Research Centre China, Beijing 102206, China
5. National Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China
6. Laboratory Animal Center, Chinese Center for Disease Control and Prevention, Beijing 102206, China
7. Clinical Research Institute, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
8. Translational in Vivo Model Research Platform, Sanofi G&D, Beijing 100022, China
- Publication Type:Journal Article
- Keywords:
Animal experiment;
ARRIVE 2.0 guidelines;
ARRIVE essential 10;
Study design;
Sample size;
Inclusion and exclusion criteria
- From:
Laboratory Animal and Comparative Medicine
2023;43(2):213-224
- CountryChina
- Language:Chinese
-
Abstract:
Improving the reproducibility of biomedical research results is a major challenge. Researchers reporting their research process transparently and accurately can help readers evaluate the reliability of the research results and further explore the experiment by repeating it or building upon its findings. The ARRIVE 2.0 guidelines, released in 2019 by the UK National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs), provide a checklist applicable to any in vivo animal research report. These guidelines aim to improve the standardization of experimental design, implementation, and reporting, as well as the reliability, repeatability, and clinical translatability of animal experimental results. The use of ARRIVE 2.0 guidelines not only enriches the details of animal experimental research reports, ensuring that information on animal experimental results is fully evaluated and utilized, but also enables readers to understand the content expressed by the author accurately and clearly, promoting the transparency and integrity of the fundamental research review process. At present, the ARRIVE 2.0 guidelines have been widely adopted by international biomedical journals. this article is a Chinese translation based on the best practices of international journals following the ARRIVE 2.0 guidelines in international journals, specifically for the complete interpretation of the ARRIVE 2.0 guidelines published in the PLoS Biology journal in 2020 (original text can be found at https://arriveguidelines.org). The first part of the article includes the preface and the "Key 10" section, which covers "study design" "sample size" and "inclusion and exclusion criteria". Its aim is to promote the full understanding and use of the ARRIVE 2.0 guidelines by domestic researchers, enhance the standardization of experimental animal research and reporting, and promote the high-quality development of experimental animal technology and comparative medicine research in China.
