Research Progress of Animal Models of Stress Cardiomyopathy
10.12300/j.issn.1674-5817.2022.102
- VernacularTitle:应激性心肌病动物模型的研究进展
- Author:
Haosheng WU
1
;
Hang SU
1
;
Chao ZHU
1
;
Wenhui WANG
1
;
Shengbing WU
2
;
Shuai CUI
2
;
Meiqi ZHOU
3
Author Information
1. Graduate School of Anhui University of Traditional Chinese Medicine, Hefei 230012, China
2. Institute of Acupuncture and Meridians, Anhui University of Traditional Chinese Medicine, Hefei 230038, China
3. Xin 'an Key Laboratory of Medical Science, Ministry of Education, Hefei 230012, China
- Publication Type:Journal Article
- Keywords:
Stress cardiomyopathy;
Animal model;
Modeling method;
Evaluation index
- From:
Laboratory Animal and Comparative Medicine
2023;43(2):173-179
- CountryChina
- Language:Chinese
-
Abstract:
Stress cardiomyopathy (SC) is an acute cardiomyopathy caused by intense mental stimulation or physical stress. Currently, few interventions are effective in reducing mortality, improving prognosis, or preventing recurrence in acute or chronic stages of SC. Therefore, it is particularly important to establish a reliable and effective SC animal model to study the pathogenesis and prevention of SC. In this paper, the preparation methods and evaluation indexes of SC models at home and abroad were reviewed, including the operation details of catecholamine hormone injection method, binding method, binding combined with electroshock method, binding combined with dehydration method, vagus nerve electrical stimulation and other modeling methods, as well as evaluation indexes such as open field test, cardiac ultrasound, electrocardiogram and ELISA, striving to provide useful reference for model selection and establishment of SC research.
