Overview of Studies in Animal Models of Schizophrenia
10.12300/j.issn.1674-5817.2022.174
- VernacularTitle:精神分裂症动物模型的研究概述
- Author:
Ling HU
1
;
Zhibin HU
1
;
Yunqing HU
1
;
Yuqiang DING
1
Author Information
1. Department of Laboratory Animal Science, Fudan University, Shanghai 200032, China
- Publication Type:Journal Article
- Keywords:
Schizophrenia;
Animal models;
Behavior analysis;
Dopamine;
γ-aminobutyric acid
- From:
Laboratory Animal and Comparative Medicine
2023;43(2):145-155
- CountryChina
- Language:Chinese
-
Abstract:
Schizophrenia (SCZ) is a highly destructive and complex psychiatric disorder illness, accompanied by a variety of positive and negative symptoms along with cognitive impairment, which brings a heavy social burden. Elucidation of the pathogenesis and therapeutic development is challenging because the complex interplay between genetic risk factors and environmental factors in essential neurodevelopmental processes. Therefore, preparing appropriate animal models can help people better understanding the neurobiological basis of SCZ and provide theoretical basis for finding new treatments. In order to provide reference for the application and improvement of SCZ animal models, this commentary reviewed several main modeling methods for animal models of SCZ, including neurodevelopmental models, drug-induced animal models, and genetic models, and the behavioral evaluation, histological analysis and possible molecular mechanisms of SCZ animal models were also outlined.
